User profiles for "author:Cem Sievers"
 | Cem SieversNational Institutes of Health Verified email at nih.gov Cited by 1250 |
[HTML][HTML] Antigen processing and presentation in cancer immunotherapy
Background Knowledge about and identification of T cell tumor antigens may inform the
development of T cell receptor-engineered adoptive cell transfer or personalized cancer …
development of T cell receptor-engineered adoptive cell transfer or personalized cancer …
[PDF][PDF] Adaptive chromatin remodeling drives glioblastoma stem cell plasticity and drug tolerance
Glioblastoma, the most common and aggressive malignant brain tumor, is propagated by
stem-like cancer cells refractory to existing therapies. Understanding the molecular …
stem-like cancer cells refractory to existing therapies. Understanding the molecular …
[HTML][HTML] Hsp90 globally targets paused RNA polymerase to regulate gene expression in response to environmental stimuli
R Sawarkar, C Sievers, R Paro - Cell, 2012 - cell.com
The molecular chaperone Heat shock protein 90 (Hsp90) promotes the maturation of several
important proteins and plays a key role in development, cancer progression, and …
important proteins and plays a key role in development, cancer progression, and …
[HTML][HTML] The role of protein methyltransferases as potential novel therapeutic targets in squamous cell carcinoma of the head and neck
V Saloura, T Vougiouklakis, C Sievers, K Burkitt… - Oral oncology, 2018 - Elsevier
Squamous cell carcinoma of the head and neck is a lethal disease with suboptimal survival
outcomes and standard therapies with significant comorbidities. Whole exome sequencing …
outcomes and standard therapies with significant comorbidities. Whole exome sequencing …
Phenotypic plasticity and reduced tissue retention of exhausted tumor-infiltrating T cells following neoadjuvant immunotherapy in head and neck cancer
C Sievers, M Craveiro, J Friedman, Y Robbins, X Yang… - Cancer Cell, 2023 - cell.com
Neoadjuvant immunotherapies (NITs) have led to clinical benefits in several cancers.
Characterization of the molecular mechanisms underlying responses to NIT may lead to …
Characterization of the molecular mechanisms underlying responses to NIT may lead to …
[PDF][PDF] A multiplexed system for quantitative comparisons of chromatin landscapes
Genome-wide profiling of histone modifications can provide systematic insight into the
regulatory elements and programs engaged in a given cell type. However, conventional …
regulatory elements and programs engaged in a given cell type. However, conventional …
[HTML][HTML] Enhanced neoepitope-specific immunity following neoadjuvant PD-L1 and TGF-β blockade in HPV-unrelated head and neck cancer
JM Redman, J Friedman, Y Robbins… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND Head and neck squamous cell carcinoma not associated with HPV (HPV-
unrelated HNSCC) is associated with a high rate of recurrence and poor survival …
unrelated HNSCC) is associated with a high rate of recurrence and poor survival …
Mixture models and wavelet transforms reveal high confidence RNA-protein interaction sites in MOV10 PAR-CLIP data
C Sievers, T Schlumpf, R Sawarkar… - Nucleic acids …, 2012 - academic.oup.com
Abstract The Photo-Activatable Ribonucleoside-enhanced CrossLinking and
ImmunoPrecipitation (PAR-CLIP) method was recently developed for global identification of …
ImmunoPrecipitation (PAR-CLIP) method was recently developed for global identification of …
The tumor microenvironment state associates with response to HPV therapeutic vaccination in patients with respiratory papillomatosis
Recurrent respiratory papillomatosis (RRP) is a rare, debilitating neoplastic disorder caused
by chronic infection with human papillomavirus (HPV) type 6 or 11 and characterized by …
by chronic infection with human papillomavirus (HPV) type 6 or 11 and characterized by …
An efficient strategy for TALEN-mediated genome engineering in Drosophila
T Katsuyama, A Akmammedov, M Seimiya… - Nucleic acids …, 2013 - academic.oup.com
In reverse genetics, a gene's function is elucidated through targeted modifications in the
coding region or associated DNA cis-regulatory elements. To this purpose, recently …
coding region or associated DNA cis-regulatory elements. To this purpose, recently …