Inherent difficulties with blocking many desirable targets using conventional approaches
have prompted many to consider using RNA interference (RNAi) as a therapeutic approach …

Background The mechanisms of paraneoplastic thrombocytosis in ovarian cancer and the
role that platelets play in abetting cancer growth are unclear. Methods We analyzed clinical …

The miR-200 family is well known to inhibit the epithelial–mesenchymal transition,
suggesting it may therapeutically inhibit metastatic biology. However, conflicting reports …

Integrated genomic analyses revealed a miRNA-regulatory network that further defined a
robust integrated mesenchymal subtype associated with poor overall survival in 459 cases …

Ovarian cancer has a clear predilection for metastasis to the omentum, but the underlying
mechanisms involved in ovarian cancer spread are not well understood. Here, we used a …

RNA interference holds tremendous potential as a therapeutic approach, especially in the
treatment of malignant tumors. However, efficient and biocompatible delivery methods are …

MicroRNAs are small regulatory RNAs that post transcriptionally control gene expression.
Reduced expression of DICER, the enzyme involved in microRNA processing, is frequently …

As the enhanced permeation and retention (EPR) effect continues to be a controversial topic
in nanomedicine, we sought to examine EPR as a function of nanoparticle size, tumor …

Metastasis is a complex, multistep process that begins with the epithelial–mesenchymal
transition (EMT). Circulating tumor cells (CTC) are believed to have undergone EMT and …

Background We previously found focal adhesion kinase (FAK) inhibition sensitizes ovarian
cancer to taxanes; however, the mechanisms are not well understood. Methods We …