User profiles for "author:Cherlhyun Jeong"

Jeong Cherlhyun

Korea Institute of Science and Technology
Verified email at kist.re.kr
Cited by 1681

Synergistic nanomedicine by combined gene and photothermal therapy

J Kim, J Kim, C Jeong, WJ Kim - Advanced drug delivery reviews, 2016 - Elsevier
To date, various nanomaterials with the ability for gene delivery or photothermal effect have
been developed in the field of biomedicine. The therapeutic potential of these nanomaterials …

[HTML][HTML] Direct observation of DNA target searching and cleavage by CRISPR-Cas12a

Y Jeon, YH Choi, Y Jang, J Yu, J Goo, G Lee… - Nature …, 2018 - nature.com
Cas12a (also called Cpf1) is a representative type VA CRISPR effector RNA-guided DNA
endonuclease, which provides an alternative to type II CRISPR–Cas9 for genome editing …

MutS switches between two fundamentally distinct clamps during mismatch repair

C Jeong, WK Cho, KM Song, C Cook… - Nature structural & …, 2011 - nature.com
Single-molecule trajectory analysis has suggested DNA repair proteins may carry out a one-
dimensional (1D) search on naked DNA encompassing> 10,000 nucleotides. Organized …

Exosome as a vehicle for delivery of membrane protein therapeutics, PH20, for enhanced tumor penetration and antitumor efficacy

Y Hong, GH Nam, E Koh, S Jeon… - Advanced Functional …, 2018 - Wiley Online Library
As biochemical and functional studies of membrane protein remain a challenge, there is
growing interest in the application of nanotechnology to solve the difficulties of developing …

[PDF][PDF] ATP alters the diffusion mechanics of MutS on mismatched DNA

WK Cho, C Jeong, D Kim, M Chang, KM Song, J Hanne… - Structure, 2012 - cell.com
The mismatch repair (MMR) initiation protein MutS forms at least two types of sliding clamps
on DNA: a transient mismatch searching clamp (∼ 1 s) and an unusually stable (∼ 600 s) …

[HTML][HTML] Quantification of purified endogenous miRNAs with high sensitivity and specificity

S Shin, Y Jung, H Uhm, M Song, S Son, J Goo… - Nature …, 2020 - nature.com
Abstract MicroRNAs (miRNAs) are short (19–24 nt) non-coding RNAs that suppress the
expression of protein coding genes at the post-transcriptional level. Differential expression …

[HTML][HTML] Direct evaluation of self-quenching behavior of fluorophores at high concentrations using an evanescent field

W Bae, TY Yoon, C Jeong - PloS one, 2021 - journals.plos.org
The quantum yield of a fluorophore is reduced when two or more identical fluorophores are
in close proximity to each other. The study of protein folding or particle aggregation is can be …

[HTML][HTML] Statin-mediated inhibition of RAS prenylation activates ER stress to enhance the immunogenicity of KRAS mutant cancer

GH Nam, M Kwon, H Jung, E Ko, SA Kim… - … for ImmunoTherapy of …, 2021 - ncbi.nlm.nih.gov
Background Statins preferentially promote tumor-specific apoptosis by depleting isoprenoid
such as farnesyl pyrophosphate and geranylgeranyl pyrophosphate. However, statins have …

[HTML][HTML] In situ immunogenic clearance induced by a combination of photodynamic therapy and rho-kinase inhibition sensitizes immune checkpoint blockade …

S Kim, SA Kim, GH Nam, Y Hong, GB Kim… - … for ImmunoTherapy of …, 2021 - ncbi.nlm.nih.gov
Background Uveal melanoma (UM) is the most frequent intraocular malignancy and is
resistant to immunotherapy. Nearly 50% of patients with UM develop metastatic disease …

Nanocage‐therapeutics prevailing phagocytosis and immunogenic cell death awakens immunity against cancer

EJ Lee, GH Nam, NK Lee, M Kih, E Koh… - Advanced …, 2018 - Wiley Online Library
A growing appreciation of the relationship between the immune system and the
tumorigenesis has led to the development of strategies aimed at “re‐editing” the immune …