User profiles for "author:Cherlhyun Jeong"
Jeong CherlhyunKorea Institute of Science and Technology Verified email at kist.re.kr Cited by 1681 |
Synergistic nanomedicine by combined gene and photothermal therapy
To date, various nanomaterials with the ability for gene delivery or photothermal effect have
been developed in the field of biomedicine. The therapeutic potential of these nanomaterials …
been developed in the field of biomedicine. The therapeutic potential of these nanomaterials …
[HTML][HTML] Direct observation of DNA target searching and cleavage by CRISPR-Cas12a
Cas12a (also called Cpf1) is a representative type VA CRISPR effector RNA-guided DNA
endonuclease, which provides an alternative to type II CRISPR–Cas9 for genome editing …
endonuclease, which provides an alternative to type II CRISPR–Cas9 for genome editing …
MutS switches between two fundamentally distinct clamps during mismatch repair
Single-molecule trajectory analysis has suggested DNA repair proteins may carry out a one-
dimensional (1D) search on naked DNA encompassing> 10,000 nucleotides. Organized …
dimensional (1D) search on naked DNA encompassing> 10,000 nucleotides. Organized …
Exosome as a vehicle for delivery of membrane protein therapeutics, PH20, for enhanced tumor penetration and antitumor efficacy
As biochemical and functional studies of membrane protein remain a challenge, there is
growing interest in the application of nanotechnology to solve the difficulties of developing …
growing interest in the application of nanotechnology to solve the difficulties of developing …
[PDF][PDF] ATP alters the diffusion mechanics of MutS on mismatched DNA
The mismatch repair (MMR) initiation protein MutS forms at least two types of sliding clamps
on DNA: a transient mismatch searching clamp (∼ 1 s) and an unusually stable (∼ 600 s) …
on DNA: a transient mismatch searching clamp (∼ 1 s) and an unusually stable (∼ 600 s) …
[HTML][HTML] Quantification of purified endogenous miRNAs with high sensitivity and specificity
S Shin, Y Jung, H Uhm, M Song, S Son, J Goo… - Nature …, 2020 - nature.com
Abstract MicroRNAs (miRNAs) are short (19–24 nt) non-coding RNAs that suppress the
expression of protein coding genes at the post-transcriptional level. Differential expression …
expression of protein coding genes at the post-transcriptional level. Differential expression …
[HTML][HTML] Direct evaluation of self-quenching behavior of fluorophores at high concentrations using an evanescent field
The quantum yield of a fluorophore is reduced when two or more identical fluorophores are
in close proximity to each other. The study of protein folding or particle aggregation is can be …
in close proximity to each other. The study of protein folding or particle aggregation is can be …
[HTML][HTML] Statin-mediated inhibition of RAS prenylation activates ER stress to enhance the immunogenicity of KRAS mutant cancer
Background Statins preferentially promote tumor-specific apoptosis by depleting isoprenoid
such as farnesyl pyrophosphate and geranylgeranyl pyrophosphate. However, statins have …
such as farnesyl pyrophosphate and geranylgeranyl pyrophosphate. However, statins have …
[HTML][HTML] In situ immunogenic clearance induced by a combination of photodynamic therapy and rho-kinase inhibition sensitizes immune checkpoint blockade …
Background Uveal melanoma (UM) is the most frequent intraocular malignancy and is
resistant to immunotherapy. Nearly 50% of patients with UM develop metastatic disease …
resistant to immunotherapy. Nearly 50% of patients with UM develop metastatic disease …
Nanocage‐therapeutics prevailing phagocytosis and immunogenic cell death awakens immunity against cancer
A growing appreciation of the relationship between the immune system and the
tumorigenesis has led to the development of strategies aimed at “re‐editing” the immune …
tumorigenesis has led to the development of strategies aimed at “re‐editing” the immune …