Background Immunotherapy against solid tumors has long been hampered by the
development of immunosuppressive tumor microenvironment, and the lack of a specific …

HLA‐G is considered as an immune checkpoint protein and a tumor‐associated antigen. In
the previous work, it is reported that CAR‐NK targeting of HLA‐G can be used to treat certain …

Background Overactivated microglia that cluster at neuritic plaques constantly release
neurotoxins, which actively contribute to progressive neurodegeneration in Alzheimer's …

Mesenchymal stem cells (MSC) are strongly associated with tumor progression and have
been used as novel cell-based agents to deliver anticancer drugs to tumors. However …

The dysregulation of microRNA expression in cancer has been associated with the epithelial-
mesenchymal transition (EMT) that triggers invasive ability and increases therapeutic …

Background: Glioblastoma (GBM) is the most common primary malignant brain tumor in
adults. It is highly resistant to chemotherapy, and tumor recurrence is common. Neuronal …

The RNA-binding protein Musashi-1 (MSI1) exerts essential roles in multiple cellular
functions, such as maintenance of self-renewal and pluripotency of stem cells. MSI1 …

Oncostatin M (OSM) is linked with multiple biological responses including growth and
differentiation. Previous reports showed inhibitory effects of OSM in tumor progression while …

Objective EpCAM is a transmembrane glycoprotein that functions as an epithelial marker in
endometrial tissues. However, the correlation between EpCAM and endometrial carcinoma …

Chemotherapy, in combination with immune checkpoint blockade (ICB) targeting to
programmed death‐1 (PD‐1) or its ligand PD‐L1, is one of the first‐line treatments for …