Due to their robust immunomodulatory capabilities, mesenchymal stem/stromal cells (MSCs)
have been used as a cellular therapy for a number of human diseases. Part of the …

Over the past two decades, immune cell therapy has emerged as a potent treatment for
multiple cancers, first through groundbreaking leukemia therapy, and more recently, by …

Natural killer (NK) cells play a crucial role in host immunity by detecting cells that
downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in …

Subsets of natural killer (NK) cells are characterized by the expression of inhibitory and/or
stimulatory receptors specific for major histocompatibility complex (MHC) class I …

Background: CTL019 is an investigational therapy derived from autologous T-cells
expressing a CD19-specific chimeric antigen receptor (CAR). A single center, phase I/IIa trial …

Interleukin‐7 (IL‐7) is required for the development and survival of T cells and plays a critical
role in modulating T‐cell homeostasis. This review will address current understanding of IL …

The next generation of therapeutic products to be approved for the clinic is anticipated to be
cell therapies, termed “living drugs” for their capacity to dynamically and temporally respond …

Background Chimeric antigen receptor (CAR) T cells have demonstrated high clinical
response rates against hematological malignancies (eg, CD19+ cancers) but have shown …

Macrophages armed with chimeric antigen receptors (CARs) provide a potent new option for
treating solid tumors. However, genetic engineering and scalable production of somatic …

Mesenchymal stem cells (MSCs) have immunosuppressive and tissue repair properties, but
clinical trials using MSCs to prevent or treat graft-versus-host disease (GVHD) have shown …