Background & Aims: Photodynamic therapy (PDT) for unresectable cholangiocarcinoma is
associated with improvement in cholestasis, quality of life, and potentially survival. We …

Mutations in TP53 lead to a defective G1 checkpoint and the dependence on checkpoint
kinase 1 (Chk1) for G2 or S phase arrest in response to DNA damage. In preclinical studies …

Background Breast cancer remains a leading cause of cancer death worldwide. There is
evidence that immunotherapy may play a role in the eradication of residual disease. Peptide …

Apocrine carcinomas comprise∼ 1% of all breast cancers and are characterized by large
cells bearing abundant eosinophilic granular cytoplasm, round nuclei, and prominent …

Vaccine therapies for treatment and prevention of cancer have seen modest degrees of
efficacy with wide variation related to the tumor type, vaccine type, adjuvants and clinical …

Background Radiation therapy (XRT) is an important modality in the treatment of cancer, and
XRT is now commonly utilized in the treatment of early-stage breast cancer. However, its use …

This paper describes the design of an early phase, prospective trial evaluating the safety
and tolerability of the combination of the histone deacetylase inhibitor, entinostat, in …

Background Anthracyclines and Herceptin are well known amongst chemotherapeutic
agents to cause cardiotoxicity. Anthracyclines, particularly in combination with, Herceptin are …

Objectives: Photodynamic therapy (PDT) for unresectable cholangiocarcinoma reportedly
results in reduction of cholestasis, improved quality of life, and improved survival. We report …