To identify common genetic variants that contribute to lung cancer susceptibility, we
conducted a multistage genome-wide association study of lung cancer in Asian women who …

Background: Studies of related individuals have consistently demonstrated notable familial
aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable …

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain
only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage …

The early onset breast cancer patients (age≤ 40) often display higher incidence of axillary
lymph node metastasis, and poorer five-year survival than the late-onset patients. To identify …

Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct
cancers to a small region of 63 000 bp on chromosome 5p15. 33. This region harbors the …

Background Mitochondrial Lon is a chaperone and DNA-binding protein that functions in
protein quality control and stress response pathways. The level of Lon regulates …

During hypoxia, FUNDC1 acts as a mitophagy receptor and accumulates at the ER
(endoplasmic reticulum)-mitochondria contact sites (EMC), also called mitochondria …

Recent evidence from several relatively small nested case‐control studies in prospective
cohorts shows an association between longer telomere length measured phenotypically in …

Background & Aims Many patients with pancreatic ductal adenocarcinoma (PDAC) develop
recurrent or metastatic diseases after surgery, so it is important to identify those most likely to …

Mitochondrial Lon is a chaperone protein whose upregulation increases the production of
mitochondrial reactive oxygen species (ROS). However, there is a lack of information in …