[HTML][HTML] BYON4228 is a pan-allelic antagonistic SIRPα antibody that potentiates destruction of antibody-opsonized tumor cells and lacks binding to SIRPγ on T cells

MJ van Helden, SA Zwarthoff, RJ Arends… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Preclinical studies have firmly established the CD47-signal-regulatory protein
(SIRP) α axis as a myeloid immune checkpoint in cancer, and this is corroborated by …

Rapid buffer and ligand screening for affinity chromatography by multiplexed Surface Plasmon Resonance imaging

KPM Geuijen, DEJW van Wijk‐Basten… - Biotechnology …, 2017 - Wiley Online Library
Protein purifications are often based on the principle of affinity chromatography, where the
protein of interest selectively binds to an immobilized ligand. The development of affinity …

1160 Phosphonate-antibody-drug conjugates: a novel immunostimulatory class of ADCs driving inside-out activation of Vγ9Vδ2 T cells leading to selective tumor cell …

MJ van Helden, RC Elgersma, DWJ van Kuppeveld… - 2023 - jitc.bmj.com
Background Gamma delta (γδ) T cells are cytotoxic effector cells that can recognize and kill
tumor cells in a major histocompatibility complex (MHC)-independent fashion. Their …

Aminopeptidases A and B from Aspergillus niger have different substrate specificities

DEJW van Wijk-Basten, S Boeren… - … from Aspergillus niger - search.proquest.com
We have cloned and characterized Aminopeptidase B from Aspergillus niger which is
involved in intracellular peptide catabolism. The inferred amino acid sequence shows 40 …

Characterization of an Aspergillus niger prolyl aminopeptidase

DEJW van Wijk-Basten, APHA Moers… - … from Aspergillus niger - search.proquest.com
We have cloned the prolyl aminopeptidase encoding gene from Aspergillus niger (papA).
cell extracts of strains overexpressing the gene using its own promoter showed a 3 to 5 fold …