The high metabolic rate of tumours often leads to acidosis and hypoxia in poorly perfused
regions. Tumour cells have thus evolved the ability to function in a more acidic environment …

It is now accepted that the growth of solid tumours is dependent on their capacity to acquire
a blood supply, and much effort has been directed towards the development of agents …

DNA-encoded chemical libraries (DELs) represent a versatile and powerful technology
platform for the discovery of small-molecule ligands to protein targets of biological and …

Revised Manuscript Received July 11, 1989 abstract: Stereospecific* H and 13C NMR
assignments were made for the two diastereotopic methyl groups of the 14 valyl and leucyl …

We report the construction and the use of a phage display human antibody library (> 3× 10 8
clones) based on principles of protein design. A large repertoire of functional antibodies with …

A nuclear magnetic resonance (NMR) structure determination is reported for the polypeptide
chain of a globular protein in strongly denaturing solution. Nuclear Overhauser effect (NOE) …

We recently demonstrated that a human recombinant scFv, L19, reacting with the ED‐B
domain of fibronectin, a marker of angiogenesis, selectively targets tumoral vasculature in …

Purpose: ED-B fibronectin is expressed only during angiogenic processes and in tissues
undergoing growth and/or extensive remodeling. We demonstrated previously the possibility …

The isolation of molecules capable of high-affinity and specific binding to biological targets
is a central problem in chemistry, biology and pharmaceutical sciences. Here we describe …

Angiogenic processes depend on the precise coordination of different cell types and a
complex exchange of signals, many of which derive from new specific components of the …