Immune modulation in cancer with antibodies

DB Page, MA Postow, MK Callahan… - Annual review of …, 2014 - annualreviews.org
Ipilimumab is the prototypical immunomodulatory antibody, approved by the FDA in 2011 for
advanced melanoma on the basis of survival benefit. Since that time, we have made …

Current landscape of immunotherapy in breast cancer: a review

S Adams, ME Gatti-Mays, K Kalinsky, LA Korde… - JAMA …, 2019 - jamanetwork.com
Importance There is tremendous interest in using immunotherapy to treat breast cancer, as
evidenced by the more than 290 clinical trials ongoing at the time of this narrative review …

[HTML][HTML] Novel technologies and emerging biomarkers for personalized cancer immunotherapy

J Yuan, PS Hegde, R Clynes, PG Foukas… - … for immunotherapy of …, 2016 - Springer
The culmination of over a century's work to understand the role of the immune system in
tumor control has led to the recent advances in cancer immunotherapies that have resulted …

[HTML][HTML] Video versus direct laryngoscopy for tracheal intubation of critically ill adults

ME Prekker, BE Driver, SA Trent… - … England Journal of …, 2023 - Mass Medical Soc
Background Whether video laryngoscopy as compared with direct laryngoscopy increases
the likelihood of successful tracheal intubation on the first attempt among critically ill adults is …

Single‐institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: lymphocyte count after 2 doses correlates with …

GY Ku, J Yuan, DB Page… - … Journal of the …, 2010 - Wiley Online Library
BACKGROUND: Ipilimumab is a monoclonal antibody that antagonizes cytotoxic T
lymphocyte antigen‐4, a negative regulator of the immune system. The authors report on …

Autoimmune bullous skin disorders with immune checkpoint inhibitors targeting PD-1 and PD-L1

J Naidoo, K Schindler, C Querfeld, K Busam… - Cancer immunology …, 2016 - AACR
Monoclonal antibodies (mAb) targeting immune checkpoint pathways such as cytotoxic T-
lymphocyte–associated protein 4 (CTLA-4) and programmed death 1 (PD-1) may confer …

A pilot study of preoperative single-dose ipilimumab and/or cryoablation in women with early-stage breast cancer with comprehensive immune profiling

HL McArthur, A Diab, DB Page, J Yuan… - Clinical Cancer …, 2016 - AACR
Purpose: To assess the safety and tolerability of preoperative cryoablation-mediated tumor
antigen presentation and/or ipilimumab-mediated immune modulation in women with …

Effect of use of a bougie vs endotracheal tube with stylet on successful intubation on the first attempt among critically ill patients undergoing tracheal intubation: a …

BE Driver, MW Semler, WH Self, AA Ginde, SA Trent… - Jama, 2021 - jamanetwork.com
Importance For critically ill adults undergoing emergency tracheal intubation, failure to
intubate the trachea on the first attempt occurs in up to 20% of cases and is associated with …

Tumor mutational burden is a determinant of immune-mediated survival in breast cancer

A Thomas, ED Routh, A Pullikuth, G Jin, J Su… - …, 2018 - Taylor & Francis
Mounting evidence supports a role for the immune system in breast cancer outcomes. The
ability to distinguish highly immunogenic tumors susceptible to anti-tumor immunity from …

[HTML][HTML] If we build it they will come: targeting the immune response to breast cancer

ME Gatti-Mays, JM Balko, SR Gameiro, HD Bear… - NPJ breast …, 2019 - nature.com
Historically, breast cancer tumors have been considered immunologically quiescent, with
the majority of tumors demonstrating low lymphocyte infiltration, low mutational burden, and …