Human behavioral ecology (HBE) is the study of human behavior from an adaptive
perspective. It focuses in particular on how human behavior varies with ecological context …

DNA topoisomerases are essential enzymes in all cell types and have been found to be
valuable drug targets both for antibacterial and anti-cancer chemotherapy. Type II …

Immunotherapy is associated with durable clinical benefit in patients with melanoma. The
goal of this article is to provide evidence‑based consensus recommendations for the use of …

Background Depression commonly complicates treatment with the cytokine interferon alfa-
2b. Laboratory animals pretreated with antidepressants have less severe depression-like …

Background Stimulating an immune response against cancer with the use of vaccines
remains a challenge. We hypothesized that combining a melanoma vaccine with interleukin …

We have previously shown that the risk of major depression in patients with malignant
melanoma undergoing interferon-α (IFN-α) therapy can be reduced by pretreatment with the …

FERRITINis important in iron homeostasis. Its twenty-four chains of two types, H and L,
assemble as a hollow shell providing an iron-storage cavity1–3. Ferritin molecules in cells …

Objective: To determine the risks of hospitalisation for bleeding peptic ulcer with the current
prophylactic aspirin regimens of 300 mg daily or less. Design: A case-control study with …

MRC Group in Protein Structure and Function, Department of Biochemistry, University of
Alberta, Edmonton, Alberta, Canada T6G 2H7, and Department of Chemistry, University of …

BACKGROUND: Tryptophan (TRP) degradation into kynurenine (KYN) by the enzyme,
indoleamine-2, 3-dioxygenase, during immune activation may contribute to development of …