The enzymatic mechanism of monolignol polymerization in lignin biosynthesis is not known,
although it has been the subject of significant interest for more than 60 years. Peroxidase …

The concept of radioguided surgery, which was first developed some 60 years ago, involves
the use of a radiation detection probe system for the intraoperative detection of …

In January 2019, a group of basic, translational, and clinical investigators and patient
advocates assembled in Miami, Florida, to discuss the current state of the science of low-grade …

Background Rucaparib, a poly(ADP-ribose) polymerase inhibitor, has anticancer activity in
recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome-…

Background Poly(ADP-ribose) polymerase (PARP) inhibitors have activity in ovarian
carcinomas with homologous recombination deficiency. Along with BRCA1 and BRCA2 (BRCA) …

This selection from the NCCN Guidelines for Ovarian Cancer focuses on the less common
ovarian histopathologies (LCOHs), because new algorithms were added for LCOHs and …

BRCA reversion mutations are detected in cfDNA from platinum-resistant or platinum-refractory
HGOC and are associated with decreased clinical benefit from rucaparib treatment. …

PURPOSE Pembrolizumab demonstrated durable antitumor activity in patients with
previously treated, advanced microsatellite instability–high or mismatch repair–deficient (MSI-H/…

Epithelial ovarian cancer is the leading cause of death from gynecologic cancer in the United
States and is the country’s fifth most common cause of cancer mortality in women. A major …

Background Platinum-based chemotherapy doublets are a standard of care for women with
ovarian cancer recurring 6 months after completion of initial therapy. In this study, we aimed …