A clear contribution of the immune system to eradication of tumors has been supported by
recent developments in the field of immunotherapy. Durable clinical responses obtained …

Using transgenic mouse models, cell line-based functional studies, and clinical specimens,
we show that cyclin D1/CDK4 mediate resistance to targeted therapy for HER2-positive …

Motivation: Given the thousands of genes and the small number of samples, gene selection
has emerged as an important research problem in microarray data analysis. Support Vector …

Pulmonary infection with an exaggerated inflammatory response is the major cause of
morbidity and mortality in cystic fibrosis (CF). The objective of this study was to determine …

Importance Patients with cancer are at increased risk for severe COVID-19, but it is unknown
whether SARS-CoV-2 vaccination is effective for them. Objective To determine the …

Aberrations in epigenetic processes, such as histone methylation, can cause cancer.
Retinoblastoma binding protein 2 (RBP2; also called JARID1A or KDM5A) can demethylate …

Background Emerging data suggest variability in susceptibility and outcome to coronavirus
disease 2019 (COVID-19) infection. Identifying risk factors associated with infection and …

Background We previously identified a functional variant in a let-7 microRNA (miRNA)
complementary site in the 3′-untranslated region of the KRAS oncogene (rs61764370) …

Purpose: To investigate the antitumor activity and safety of paclitaxel in patients with
advanced human immunodeficiency virus (HIV)-associated Kaposi's sarcoma (KS). Patients …

Upregulation of MYC is a common driver event in human cancers, and some tumors depend
on MYC to maintain transcriptional programs that promote cell growth and proliferation …