Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab
Immune checkpoint blockade (ICB) provides clinical benefit to a subset of patients with
cancer. However, existing biomarkers do not reliably predict treatment response across …
cancer. However, existing biomarkers do not reliably predict treatment response across …
[HTML][HTML] Long read nanopore sequencing for detection of HLA and CYP2D6 variants and haplotypes
Haplotypes are often critical for the interpretation of genetic laboratory observations into
medically actionable findings. Current massively parallel DNA sequencing technologies …
medically actionable findings. Current massively parallel DNA sequencing technologies …
Chromatin is an ancient innovation conserved between Archaea and Eukarya
R Ammar, D Torti, K Tsui, M Gebbia, T Durbic… - Elife, 2012 - elifesciences.org
The eukaryotic nucleosome is the fundamental unit of chromatin, comprising a protein
octamer that wraps∼ 147 bp of DNA and has essential roles in DNA compaction, replication …
octamer that wraps∼ 147 bp of DNA and has essential roles in DNA compaction, replication …
[HTML][HTML] Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations
The evolution of drug resistance in fungal pathogens compromises the efficacy of the limited
number of antifungal drugs. Drug combinations have emerged as a powerful strategy to …
number of antifungal drugs. Drug combinations have emerged as a powerful strategy to …
Exon-based phylogenomics strengthens the phylogeny of Neotropical cichlids and identifies remaining conflicting clades (Cichliformes: Cichlidae: Cichlinae)
KL Ilves, D Torti, H López-Fernández - Molecular Phylogenetics and …, 2018 - Elsevier
The phenotypic, geographic, and species diversity of cichlid fishes have made them a group
of great interest for studying evolutionary processes. Here we present a targeted-exon next …
of great interest for studying evolutionary processes. Here we present a targeted-exon next …
[HTML][HTML] Early Cancer Detection in Li–Fraumeni Syndrome with Cell-Free DNA
Abstract People with Li–Fraumeni syndrome (LFS) harbor a germline pathogenic variant in
the TP53 tumor suppressor gene, face a near 100% lifetime risk of cancer, and routinely …
the TP53 tumor suppressor gene, face a near 100% lifetime risk of cancer, and routinely …
[HTML][HTML] Antitumor immune effects of preoperative sitravatinib and nivolumab in oral cavity cancer: SNOW window-of-opportunity study
Background Sitravatinib, a tyrosine kinase inhibitor that targets TYRO3, AXL, MERTK and
the VEGF receptor family, is predicted to increase the M1 to M2-polarized tumor-associated …
the VEGF receptor family, is predicted to increase the M1 to M2-polarized tumor-associated …
Clinical impact of combined epigenetic and molecular analysis of pediatric low-grade gliomas
K Fukuoka, Y Mamatjan, R Tatevossian… - Neuro …, 2020 - academic.oup.com
Background Both genetic and methylation analysis have been shown to provide insight into
the diagnosis and prognosis of many brain tumors. However, the implication of methylation …
the diagnosis and prognosis of many brain tumors. However, the implication of methylation …
CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome
LE Heisler, D Torti, PC Boutros, J Watson… - Nucleic acids …, 2005 - academic.oup.com
An effective tool for the global analysis of both DNA methylation status and protein–
chromatin interactions is a microarray constructed with sequences containing regulatory …
chromatin interactions is a microarray constructed with sequences containing regulatory …
[HTML][HTML] A genome scale overexpression screen to reveal drug activity in human cells
A Arnoldo, S Kittanakom, LE Heisler, AB Mak… - Genome medicine, 2014 - Springer
Target identification is a critical step in the lengthy and expensive process of drug
development. Here, we describe a genome-wide screening platform that uses systematic …
development. Here, we describe a genome-wide screening platform that uses systematic …