The incidence and mortality of small-cell lung cancer worldwide make this disease a notable
health-care issue. Diagnosis relies on histology, with the use of immunohistochemical …

Arginine, a semi‐essential amino acid in humans, is critical for the growth of human cancers,
particularly those marked by de novo chemoresistance and a poor clinical outcome. In …

Recent research has demonstrated that microRNAs (miRNAs) are key regulators of many
cell processes often deregulated in cancer, including apoptosis. Indeed, it is becoming clear …

Background Among patients with non–small-cell lung cancer (NSCLC), data on intratumor
heterogeneity and cancer genome evolution have been limited to small retrospective …

The early detection of relapse following primary surgery for non-small-cell lung cancer and
the characterization of emerging subclones, which seed metastatic sites, might offer new …

Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through
human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the …

Lung cancer is the leading cause of cancer-associated mortality worldwide. Here we
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 …

With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we
demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab …

Background New therapeutic strategies for malignant mesothelioma are urgently needed. In
the DETERMINE study, we investigated the effects of the cytotoxic-T-lymphocyte-associated …

Metastatic disease is responsible for the majority of cancer-related deaths. We report the
longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from …