[HTML][HTML] Current strategies in engaging oncolytic viruses with antitumor immunity
DA Boagni, D Ravirala, SX Zhang - Molecular Therapy-Oncolytics, 2021 - cell.com
Oncolytic virotherapy has produced promising yet limited results in preclinical and clinical
studies. Besides direct oncolytic activity, a significant therapeutic mechanism of oncolytic …
studies. Besides direct oncolytic activity, a significant therapeutic mechanism of oncolytic …
[HTML][HTML] Co-delivery of novel bispecific and trispecific engagers by an amplicon vector augments the therapeutic effect of an HSV-based oncolytic virotherapy
D Ravirala, B Mistretta, PH Gunaratne… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Although oncolytic virotherapy has shown substantial promises as a new
treatment modality for many malignancies, further improvement on its therapeutic efficacy …
treatment modality for many malignancies, further improvement on its therapeutic efficacy …
Comprehensive characterization of tumor immune landscape following oncolytic virotherapy by single-cell RNA sequencing
An important mechanism of oncolytic virotherapy in ameliorating cancer immunotherapy is
by inducing significant changes in the immune landscape in the tumor microenvironment …
by inducing significant changes in the immune landscape in the tumor microenvironment …
[HTML][HTML] Single-cell RNA sequencing reveals a strong connection between Gadd45g upregulation and oncolytic HSV infection in tumor tissue
The oncolytic effect of virotherapy derives from the intrinsic capability of the applied virus in
selectively infecting and killing tumor cells. Although oncolytic viruses of various …
selectively infecting and killing tumor cells. Although oncolytic viruses of various …
Engaging Immune Cells within the Tumor Microenvironment to Enhance Efficacy of Oncolytic Virotherapy
DP Ravirala - 2021 - uh-ir.tdl.org
Oncolytic viruses are particularly attractive for many of the current cancer-
immunotherapeutic modalities in their capacity to simultaneously cause direct lysis of tumor …
immunotherapeutic modalities in their capacity to simultaneously cause direct lysis of tumor …