[HTML][HTML] Current strategies in engaging oncolytic viruses with antitumor immunity

DA Boagni, D Ravirala, SX Zhang - Molecular Therapy-Oncolytics, 2021 - cell.com
Oncolytic virotherapy has produced promising yet limited results in preclinical and clinical
studies. Besides direct oncolytic activity, a significant therapeutic mechanism of oncolytic …

[HTML][HTML] Co-delivery of novel bispecific and trispecific engagers by an amplicon vector augments the therapeutic effect of an HSV-based oncolytic virotherapy

D Ravirala, B Mistretta, PH Gunaratne… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Although oncolytic virotherapy has shown substantial promises as a new
treatment modality for many malignancies, further improvement on its therapeutic efficacy …

Comprehensive characterization of tumor immune landscape following oncolytic virotherapy by single-cell RNA sequencing

D Ravirala, G Pei, Z Zhao, X Zhang - Cancer Immunology, Immunotherapy, 2022 - Springer
An important mechanism of oncolytic virotherapy in ameliorating cancer immunotherapy is
by inducing significant changes in the immune landscape in the tumor microenvironment …

[HTML][HTML] Single-cell RNA sequencing reveals a strong connection between Gadd45g upregulation and oncolytic HSV infection in tumor tissue

D Ravirala, G Pei, Z Zhao, X Zhang - Molecular Therapy-Oncolytics, 2021 - cell.com
The oncolytic effect of virotherapy derives from the intrinsic capability of the applied virus in
selectively infecting and killing tumor cells. Although oncolytic viruses of various …

Engaging Immune Cells within the Tumor Microenvironment to Enhance Efficacy of Oncolytic Virotherapy

DP Ravirala - 2021 - uh-ir.tdl.org
Oncolytic viruses are particularly attractive for many of the current cancer-
immunotherapeutic modalities in their capacity to simultaneously cause direct lysis of tumor …