Piwi proteins specify an animal-specific subclass of the Argonaute family that, in vertebrates,
is specifically expressed in germ cells. We demonstrate that zebrafish Piwi (Ziwi) is …

Approaches to treat cancer with therapeutic vaccination have made significant progress. In
order to induce efficient antitumor immunity, a vaccine should target and activate antigen …

ADP‐ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad
functions, including roles in stress responses elicited, for example, by DNA damage and …

The proteasome is an essential evolutionary conserved protease involved in many
regulatory systems. Here, we describe the synthesis and characterization of the activity …

G protein-coupled receptors (GPCRs) mediate the perception of smell, light, taste, and pain.
They are involved in signal recognition and cell communication and are some of the most …

Covalent conjugation of Toll-like receptor ligands (TLR-L) to synthetic antigenic peptides
strongly improves antigen presentation in vitro and T lymphocyte priming in vivo. These …

Chikungunya virus (CHIKV), an Old World alphavirus, is transmitted to humans by infected
mosquitoes and causes acute rash and arthritis, occasionally complicated by neurologic …

PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity,
transcription, and DNA replication stress management. However, little is known about the …

Dendritic cells (DCs) are crucial for priming of naive CD8+ T lymphocytes to exogenous
antigens, so-called “cross-priming.” We report that exogenous protein antigen can be …

We propose a ligand screening method, called TINS (target immobilized NMR screening),
which reduces the amount of target required for the fragment-based approach to drug …