User profiles for "author:Doncho V Zhelev"

Doncho V Zhelev

University of Pittsburgh
Verified email at pitt.edu
Cited by 3030

Tension-stabilized pores in giant vesicles: determination of pore size and pore line tension

DV Zhelev, D Needham - Biochimica et Biophysica Acta (BBA) …, 1993 - Elsevier
We present the first observations of giant, long-existing, stabilized pores in vesicle
membranes. Using a new experimental technique for studying the electropermeabilization of …

[PDF][PDF] Identification of GPC2 as an oncoprotein and candidate immunotherapeutic target in high-risk neuroblastoma

KR Bosse, P Raman, Z Zhu, M Lane, D Martinez… - Cancer cell, 2017 - cell.com
We developed an RNA-sequencing-based pipeline to discover differentially expressed cell-
surface molecules in neuroblastoma that meet criteria for optimal immunotherapeutic target …

[PDF][PDF] Role of the membrane cortex in neutrophil deformation in small pipets

DV Zhelev, D Needham, RM Hochmuth - Biophysical journal, 1994 - cell.com
The simplest model for a neutrophil in its" passive" state views the cell as consisting of a
liquid-like cytoplasmic region surrounded by a membrane. The cell surface is in a state of …

Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection

W Li, C Chen, A Drelich, DR Martinez… - Proceedings of the …, 2020 - National Acad Sciences
Effective therapies are urgently needed for the SARS-CoV-2/COVID-19 pandemic. We
identified panels of fully human monoclonal antibodies (mAbs) from large phage-displayed …

[HTML][HTML] Material property characteristics for lipid bilayers containing lysolipid

DV Zhelev - Biophysical journal, 1998 - cell.com
The apparent area expansion modulus and tensile strength of egg phosphatidylcholine
(EPC) membranes are measured in the presence of monooleoylphosphatidylcholine …

[PDF][PDF] Exchange of monooleoylphosphatidylcholine as monomer and micelle with membranes containing poly (ethylene glycol)-lipid

D Needham, N Stoicheva, DV Zhelev - Biophysical journal, 1997 - cell.com
Surface-grafted polymers, such as poly (ethylene glycol)(PEG), provide an effective steric
barrier against surface-surface and surface-macromolecule interactions. In the present work …

Function and regulation of chemoattractant receptors

B Haribabu, RM Richardson, MW Verghese… - Immunologic …, 2000 - Springer
Phagocyte migration and activation at sites of inflammation is mediated through
chemoattractant receptors that are coupled to G-proteins. Early studies from our laboratory …

Lysolipid exchange with lipid vesicle membranes

D Needham, DV Zhelev - Annals of biomedical engineering, 1995 - Springer
While the aqueous solubility for bilayer phospholipids is less than 10− 10 M—keeping lipid
membranes at essentially constant mass, single chain surfactants can have a significant …

[PDF][PDF] Controlled pseudopod extension of human neutrophils stimulated with different chemoattractants

DV Zhelev, AM Alteraifi, D Chodniewicz - Biophysical journal, 2004 - cell.com
The formation of pseudopods and lamellae after ligation of chemoattractant sensitive G-
protein coupled receptors (GPCRs) is essential for chemotaxis. Here, pseudopod extension …

[PDF][PDF] A novel micropipet method for measuring the bending modulus of vesicle membranes

DV Zhelev, D Needham, RM Hochmuth - Biophysical journal, 1994 - cell.com
A theoretical model and an experiment are presented for determining the bending modulus
of a bilayer vesicle membrane. The vesicle is held with a pipet having a radius between 1 …