A long-standing paradox in cellular immunology concerns the conditional requirement for
CD4+ T-helper (TH) cells in the priming of cytotoxic CD8+ T lymphocyte (CTL) responses in …

In cancer, immune exhaustion contributes to the immunosuppressive tumor
microenvironment. Exhausted immune cells demonstrate poor effector function and …

Cancer and the immune system are intimately related. Much of the bulk of tumors is
comprised of stromal leukocytes with immune functions, which serve to both promote and …

The 'help'provided by CD4+ T lymphocytes during the priming of CD8+ T lymphocytes
confers a key feature of immune memory: the capacity for autonomous secondary expansion …

Here we have identified'triple D'(3d), a recessive N-ethyl-N-nitrosourea-induced mutation
and phenotype in which no signaling occurs via the intracellular Toll-like receptors 3, 7 and …

Cholesterol is essential for membrane synthesis; however, the mechanisms that link cellular
lipid metabolism to proliferation are incompletely understood. We demonstrate here that …

Both lipopolysaccharide (LPS) and double-stranded RNA (dsRNA) are adjuvants for the
adaptive immune response, inducing upregulation of costimulatory molecules (UCM) on …

System lupus erythematosus (SLE) is a multifactorial systemic autoimmune disease with a
wide variety of presenting features. SLE is believed to result from dysregulated immune …

Adaptive immune responses to Ags released by dying cells play a critical role in the
development of autoimmunity, allograft rejection, and spontaneous as well as therapy …

Impaired functionality of dendritic cells (DCs) significantly contributes to decreased adaptive
immune responses in aged hosts. The expression of MHC-peptide on the DC surface is the …