[HTML][HTML] Effects of belapectin, an inhibitor of galectin-3, in patients with nonalcoholic steatohepatitis with cirrhosis and portal hypertension

N Chalasani, MF Abdelmalek, G Garcia-Tsao… - Gastroenterology, 2020 - Elsevier
Background & Aims Increased levels of galectin 3 have been associated with nonalcoholic
steatohepatitis (NASH) and contribute to toxin-induced liver fibrosis in mice. GR-MD-02 …

[HTML][HTML] Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease

PG Traber, H Chou, E Zomer, F Hong, A Klyosov… - PloS one, 2013 - journals.plos.org
Galectin-3 protein is critical to the development of liver fibrosis because galectin-3 null mice
have attenuated fibrosis after liver injury. Therefore, we examined the ability of novel …

[HTML][HTML] Therapy of experimental NASH and fibrosis with galectin inhibitors

PG Traber, E Zomer - PloS one, 2013 - journals.plos.org
Non-alcoholic steatohepatitis (NASH) and resultant liver fibrosis is a major health problem
without effective therapy. Some data suggest that galectin-3 null mice are resistant to the …

[HTML][HTML] Enhancing clinical and immunological effects of anti-PD-1 with belapectin, a galectin-3 inhibitor

BD Curti, Y Koguchi, RS Leidner, AS Rolig… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background PD-1/PD-L1 engagement and overexpression of galectin-3 (Gal-3) are critical
mechanisms of tumor-induced immune suppression that contribute to immunotherapy …

DAVANAT® (GM-CT-01) and Colon Cancer: Preclinical and Clinical (Phase I and II) Studies

A Klyosov, E Zomer, D Platt - Glycobiology and drug design, 2012 - ACS Publications
DAVANAT®(trade name) or GM-CT-01 (operational name) is the galactomannan isolated
from seeds of Cyamopsis tetragonoloba, or Guar gum, and subjected to a controlled partial …

Confirmation of widespread sulfonamide contamination in northeast US market milk

SE Charm, E Zomer, R Salter - Journal of food protection, 1988 - Elsevier
Seventy percent of “off the shelf” and tanker milk tested in the northeast US was
contaminated with sulfonamide at above 5 ppb with 35% having more than 25 ppb …

Use of a new rapid bioluminescence method for screening organophosphate and N-methylcarbamate insecticides in processed baby foods

SJ Saul, E Zomer, D Puopolo, SE Charm - Journal of food protection, 1996 - Elsevier
An enzyme with high specific affinity for organophosphate and N-methylcarbamate
insecticides has been incorporated into a new test for detection of these insecticides at the …

[PDF][PDF] Preclinical studies of anticancer efficacy of 5-Fluorouracil when co-administered with the 1, 4-β-D-galactomannan

AA Klyosov, D Platt, E Zomer - Preclinica, 2003 - academia.edu
Some carbohydrates have been viewed for a long time as drugs or drug components acting
on tumor-associated targets. Various types of cellular interactions mediated by lectins have …

LC-Receptorgram: A Method for Identification and Quantitation of β-Lactams in Milk by Liquid Chromatography with Microbial Receptor Assay

E Zomer, J Quintana, S Saul… - Journal of AOAC …, 1995 - academic.oup.com
A rapid determinative method was developed for identification and quantitation of common β-
lactam drugs (eg, amoxicillin, ampicillin, cephapirin, penicillin G, ceftiofur, and cloxacillin) in …

HPLC receptorgram: a method for confirmation and identification of antimicrobial drugs by using liquid chromatography with microbial receptor assay. I. Sulfonamides …

E Zomer, S Saul, SE Charm - Journal of AOAC International, 1992 - academic.oup.com
A determinative method was developed for confirmation, identification, and quantitation of
12 sulfonamide residues and p-aminobenzoic acid (PABA) in milk. This method, termed" …