Affinity-optimized T cell receptors can enhance the potency of adoptive T cell therapy.
Afamitresgene autoleucel (afami-cel) is a human leukocyte antigen-restricted autologous T …

Drug-induced liver chemistry abnormalities, primarily transaminase elevations, are
commonly observed in pazopanib-treated patients. This meta-analysis characterises liver …

This study in patients with relapsed, refractory, or high-risk multiple myeloma (MM)
evaluated the safety and activity of autologous T cells engineered to express an affinity …

Adoptive T-cell therapy, incorporating engineered T cell receptors (TCRs) or chimeric
antigen receptors (CARs), target tumor antigens with high affinity and specificity. To increase …

102 Background: MAGE-A4 is a cancer/testis antigen with expression in many solid tumors
promoting cell growth by preventing cell cycle arrest and apoptosis. This study …

Patients with hepatocellular carcinoma (HCC) have a poor prognosis and limited therapeutic
options. Alpha‐fetoprotein (AFP) is often expressed at high levels in HCC and is an …

Background ADP-A2M10 specific peptide enhanced affinity receptor (SPEAR) T cells (ADP-
A2M10) are genetically engineered autologous T cells that express a high-affinity melanoma …

11504 Background: This phase 2, open-label trial (SPEARHEAD-1; NCT04044768) is
designed to evaluate the efficacy, safety, and tolerability of afamitresgene autoleucel in 45 …

Background Afamitresgene autoleucel (afami-cel) showed acceptable safety and promising
efficacy in a phase 1 trial (NCT03132922). The aim of this study was to further evaluate the …

Background: ADP-A2M10 specific peptide enhanced affinity receptor (SPEAR) T-cells are
genetically engineered autologous T-cells that express a high-affinity melanoma-associated …