GABARAPL1/GEC1 is an early estrogen-induced gene which encodes a protein highly
conserved from C. elegans to humans. Overexpressed GABARAPL1 interacts with GABAA …

Simple Summary Until recently, there were no approved therapies for the aggressive blood
cancer blastic plasmacytoid dendritic cell neoplasm (BPDCN). Survival for patients …

Background CAR-T cells immunotherapy is a breakthrough in the treatment of hematological
malignancies such as acute lymphoblastic leukemia (ALL) and B-cell malignancies …

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is associated with a remarkably poor
prognosis and with no treatment consensus. The identification of relevant therapeutic targets …

Blastic plasmacytoid dendritic cell neoplasm is an aggressive hematologic malignancy with
a poor prognosis. No consensus regarding optimal treatment modalities is currently …

Simple Summary We used fresh or thawed Umbilical Cord Blood (UCB) to produce CAR-T
cells directed against CD123, and we compared their functionality to Peripheral Blood (PB) …

Even if adoptive cell transfer (ACT) has already shown great clinical efficiency in different
types of disease, such as cancer, some adverse events consistently occur, and suicide …

Background CD20 is a B cell lineage–specific marker expressed by normal and leukemic B
cells and targeted by several antibody immunotherapies. We have previously shown that the …

Production of functional plasmacytoid dendritic cells – targeted chimeric antigen receptor T
cells from patients with immune-mediated inflammatory diseases | British Journal of …

With the clinical demonstration of the efficacy of immune checkpoints inhibitors,
immunotherapy has been considered in 2013 to be the major breakthrough for cancer …