[HTML][HTML] Deletion of Cbl-b inhibits CD8+ T-cell exhaustion and promotes CAR T-cell function
Background Chimeric antigen receptor (CAR) T-cell therapy is an emerging option for
cancer treatment, but its efficacy is limited, especially in solid tumors. This is partly because …
cancer treatment, but its efficacy is limited, especially in solid tumors. This is partly because …
[HTML][HTML] Identification of arrestin-3-specific residues necessary for JNK3 kinase activation
J Seo, EL Tsakem, M Breitman, VV Gurevich - Journal of Biological …, 2011 - ASBMB
Arrestins bind active phosphorylated G protein-coupled receptors, blocking G protein
activation and channeling the signaling to G protein-independent pathways. Free arrestin-3 …
activation and channeling the signaling to G protein-independent pathways. Free arrestin-3 …
Cognitive effects of dopamine depletion in the context of diminished acetylcholine signaling capacity in mice
L Zurkovsky, E Bychkov, EL Tsakem… - Disease Models & …, 2013 - journals.biologists.com
SUMMARY A subset of patients with Parkinson's disease acquires a debilitating dementia
characterized by severe cognitive impairments (ie Parkinson's disease dementia; PDD) …
characterized by severe cognitive impairments (ie Parkinson's disease dementia; PDD) …
Gut microbiota contributes to spontaneous colitis in E3 ligase itch-deficient mice
M Kathania, EL Tsakem, AL Theiss… - The Journal of …, 2020 - journals.aai.org
Inflammatory bowel diseases are associated with complex shifts in microbiota composition.
However, it remains unclear whether specific subsets of commensal bacteria induce …
However, it remains unclear whether specific subsets of commensal bacteria induce …
[HTML][HTML] Progressive reduction of its expression in rods reveals two pools of arrestin-1 in the outer segment with different roles in photoresponse recovery
WM Cleghorn, EL Tsakem, X Song, SA Vishnivetskiy… - PLoS …, 2011 - journals.plos.org
Light-induced rhodopsin signaling is turned off with sub-second kinetics by rhodopsin
phosphorylation followed by arrestin-1 binding. To test the availability of the arrestin-1 pool …
phosphorylation followed by arrestin-1 binding. To test the availability of the arrestin-1 pool …
Cellular signaling, molecular activation, and regulation of the NLRP6 inflammasome
EL Tsakem, S Mukherjee, AL Theiss… - Inflammasome Biology, 2023 - Elsevier
Abstract NLRP6 (NACHT, LRR (leucine-rich repeat), and PYD (pyrin domain) domain-
containing 6) is a member of the NLR (nucleotide-oligomerization domain-like receptor) …
containing 6) is a member of the NLR (nucleotide-oligomerization domain-like receptor) …