Vascular inflammation, infusion reactions, glomerulopathies, and other potentially adverse
effects may be observed in laboratory animals, including monkeys, on toxicity studies of …

The recent cloning of two GABAB receptor subunits, GABAB1 and GABAB2, has raised the
possibility that differences in GABAB receptor subunit composition may give rise to …

Objectives The interaction between the immune system and tumor cells is an important
feature for the prognosis and treatment of cancer. Multiplex immunohistochemistry (mIHC) …

The Nonhuman Primate in Drug Development and Safety Assessment is a valuable
reference dedicated to compiling the latest research on nonhuman primate models in …

We describe the development of novel benzimidazoles as small molecule histamine H4
receptor (H4R) antagonists and their profiling in rat early toxicity studies. The discovery and …

Abstract Wolf E, Wanke R, Schenck E, Hermanns W, Brem G. Effects of growth hormone
overproduction on grip strength of transgenic mice. Eur J Endocrinol 1995; 133: 735–40 …

Historically, histopathology evaluation is performed by a pathologist generating a qualitative
assessment on thin tissue sections on glass slides. In the past decade, there has been a …

The pancreas of MTbGH-transgenic mice exhibiting high levels of circulating growth
hormone was analyzed by morphometry. Mice that did not inherit the foreign gene served as …

The metabolism of luciferin in mice transgenic for luciferase (luc) produces light that may be
detected trans vivo by an intensified CCD camera (biophotonics). Thus, the generation of …

The anorectic drug, dexfenfluramine has been associated with an increase in the relative
risk of developing pulmonary hypertension. 5-hydroxytryptamine (5-HT) is a mitogen for …