Alzheimer's disease
An estimated 24 million people worldwide have dementia, the majority of whom are thought
to have Alzheimer's disease. Thus, Alzheimer's disease represents a major public health …
to have Alzheimer's disease. Thus, Alzheimer's disease represents a major public health …
Cognitive bias modification: A review of meta-analyses
EB Jones, L Sharpe - Journal of affective disorders, 2017 - Elsevier
Background Cognitive bias modification (CBM) is a novel, but controversial intervention with
considerable divergence amongst conclusions in individual studies and reviews. This …
considerable divergence amongst conclusions in individual studies and reviews. This …
Drug repositioning for Alzheimer's disease
A Corbett, J Pickett, A Burns, J Corcoran… - Nature reviews Drug …, 2012 - nature.com
Existing drugs for Alzheimer's disease provide symptomatic benefit for up to 12 months, but
there are no approved disease-modifying therapies. Given the recent failures of various …
there are no approved disease-modifying therapies. Given the recent failures of various …
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
L Kruidenier, C Chung, Z Cheng, J Liddle, KH Che… - Nature, 2012 - nature.com
The jumonji (JMJ) family of histone demethylases are Fe2+-and α-ketoglutarate-dependent
oxygenases that are essential components of regulatory transcriptional chromatin …
oxygenases that are essential components of regulatory transcriptional chromatin …
Type IIA topoisomerase inhibition by a new class of antibacterial agents
Despite the success of genomics in identifying new essential bacterial genes, there is a lack
of sustainable leads in antibacterial drug discovery to address increasing multidrug …
of sustainable leads in antibacterial drug discovery to address increasing multidrug …
[HTML][HTML] Hip arthroscopy versus best conservative care for the treatment of femoroacetabular impingement syndrome (UK FASHIoN): a multicentre randomised …
Background Femoroacetabular impingement syndrome is an important cause of hip pain in
young adults. It can be treated by arthroscopic hip surgery, including reshaping the hip, or …
young adults. It can be treated by arthroscopic hip surgery, including reshaping the hip, or …
Olaparib and durvalumab in patients with germline BRCA-mutated metastatic breast cancer (MEDIOLA): an open-label, multicentre, phase 1/2, basket study
Background Poly (ADP-ribose) polymerase inhibitors combined with immunotherapy have
shown antitumour activity in preclinical studies. We aimed to assess the safety and activity of …
shown antitumour activity in preclinical studies. We aimed to assess the safety and activity of …
Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders
B Jones, EL Jones, SA Bonney, HN Patel… - Nature …, 2003 - nature.com
Dietary fat is an important source of nutrition. Here we identify eight mutations in SARA2 that
are associated with three severe disorders of fat malabsorption. The Sar1 family of proteins …
are associated with three severe disorders of fat malabsorption. The Sar1 family of proteins …
[HTML][HTML] Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration
C Kleinschnitz, H Grund, K Wingler, ME Armitage… - PLoS …, 2010 - journals.plos.org
Ischemic stroke is the second leading cause of death worldwide. Only one moderately
effective therapy exists, albeit with contraindications that exclude 90% of the patients. This …
effective therapy exists, albeit with contraindications that exclude 90% of the patients. This …
Discovery and characterization of small molecule inhibitors of the BET family bromodomains
C Chung, H Coste, JH White, O Mirguet… - Journal of medicinal …, 2011 - ACS Publications
Epigenetic mechanisms of gene regulation have a profound role in normal development and
disease processes. An integral part of this mechanism occurs through lysine acetylation of …
disease processes. An integral part of this mechanism occurs through lysine acetylation of …