It is well established that tumor-associated macrophages (TAM) found in most advanced
tumors have a pro-tumoral role. In this context, TAM limit the activity of tumor-infiltrating …

Appropriate localization and migration of T cells is a prerequisite for antitumor immune
surveillance. Studies using fixed tumor samples from human patients have shown that T …

Innovative immunotherapies based on immune checkpoint targeting antibodies and
engineered T cells are transforming the way we approach cancer treatment. However …

In a large proportion of cancer patients, CD8 T cells are excluded from the vicinity of cancer
cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism …

Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration
correlates with lower patient survival and resistance to therapy. Tumor-associated …

The migration of T cells and access to tumor antigens is of utmost importance for the
induction of protective anti-tumor immunity. Once having entered a malignant site, T cells …

Only a fraction of cancer patients benefits from immune checkpoint inhibitors. This may be
partly due to the dense extracellular matrix (ECM) that forms a barrier for T cells. Comparing …

The molecular mechanisms responsible for the sustained basal motility of T cells within
lymph nodes (LNs) remain elusive. To study T cell motility in a LN environment, we have …

Neisseria meningitidis is a commensal bacterium of the human nasopharynx. Occasionally,
this bacterium reaches the bloodstream and causes meningitis after crossing the blood …

Clear cell renal cell carcinomas (RCC) frequently display inactivation of von Hippel-Lindau
(VHL) gene leading to increased level of hypoxia-inducible factors (HIF). In this study, we …