Allogeneic blood or bone-marrow transplantation (alloBMT) is a potentially curative
treatment for a variety of haematological malignancies and nonmalignant diseases …

Allogeneic hematopoietic stem cell transplantation (alloSCT) is a potentially curative therapy
for many hematologic and immunologic diseases. Further, partial or full donor hematopoietic …

The hypothesis of immunologic surveillance of neoplasia is predicated on the theory that the
immune system is capable of discriminating self from foreign antigens, and that tumor …

We evaluated the safety and efficacy of high-dose, posttransplantation cyclophosphamide
(Cy) to prevent graft rejection and graft-versus-host disease (GVHD) after outpatient …

For some time it has been thought that antigenic challenge in neonatal life is a tolerogenic
rather than immunogenic event. Reexamination of the classic neonatal tolerance …

We studied adults with acute myeloid leukemia (AML) after haploidentical (n= 192) and 8/8
HLA-matched unrelated donor (n= 1982) transplantation. Haploidentical recipients received …

Abstract The Blood and Marrow Transplant Clinical Trials Network conducted 2 parallel
multicenter phase 2 trials for individuals with leukemia or lymphoma and no suitable related …

There are three possible outcomes when a T cell recognizes a cell bearing a self or foreign
antigen.(i) The T cell is not sufficiently signaled and is unaffected.(ii) The T cell is …

Because of its potent immunosuppressive yet stem cell–sparing activity, high-dose
cyclophosphamide was tested as sole prophylaxis of graft-versus-host disease (GVHD) after …

Allogeneic marrow transplantation can cure sickle cell disease; however, HLA-matched
donors are difficult to find, and the toxicities of myeloablative conditioning are prohibitive for …