Image-guided intratumoral immunotherapy: Developing a clinically practical technology

A Som, JG Rosenboom, A Chandler, RA Sheth… - Advanced drug delivery …, 2022 - Elsevier
Immunotherapy has revolutionized the contemporary oncology landscape, with durable
responses possible across a range of cancer types. However, the majority of cancer patients …

Granzyme B PET imaging as a predictive biomarker of immunotherapy response

BM Larimer, E Wehrenberg-Klee, F Dubois, A Mehta… - Cancer research, 2017 - AACR
While cancer immunotherapy can produce dramatic responses, only a minority of patients
respond to treatment. Reliable response biomarkers are needed to identify responders, and …

Quantitative CD3 PET imaging predicts tumor growth response to anti-CTLA-4 therapy

BM Larimer, E Wehrenberg-Klee… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Immune checkpoint inhibitors have made rapid advances, resulting in multiple Food and
Drug Administration–approved therapeutics that have markedly improved survival. However …

The effectiveness of checkpoint inhibitor combinations and administration timing can be measured by granzyme B PET imaging

BM Larimer, E Bloch, S Nesti, EE Austin… - Clinical Cancer …, 2019 - AACR
Purpose: The lack of a timely and reliable measure of response to cancer immunotherapy
has confounded understanding of mechanisms of resistance and subsequent therapeutic …

Y-90 radioembolization combined with a PD-1 inhibitor for advanced hepatocellular carcinoma

E Wehrenberg-Klee, L Goyal, M Dugan, AX Zhu… - Cardiovascular and …, 2018 - Springer
Nivolumab has recently received approval by the Food and Drug Administration for
treatment of advanced hepatocellular carcinoma (HCC) in patients previously treated with …

[HTML][HTML] Transjugular intrahepatic portosystemic shunt placement for portal hypertension: meta-analysis of safety and efficacy of 8 mm vs. 10 mm stents

J Liu, EP Wehrenberg-Klee, ED Bethea… - … Research and Practice, 2020 - hindawi.com
Introduction. Hepatic encephalopathy (HE) following transjugular intrahepatic portosystemic
shunt (TIPS) placement remains a leading adverse event. Controversy remains regarding …

Patient selection and clinical outcomes of Y90 in hepatocellular carcinoma

E Wehrenberg-Klee, RT Gandhi, S Ganguli - Techniques in vascular and …, 2019 - Elsevier
Y90 radioembolization is an alternative to transarterial chemoembolization for the intra-
arterial treatment of hepatocellular carcinoma (HCC). However, the optimal treatment of …

[HTML][HTML] Granzyme B PET imaging of immune-mediated tumor killing as a tool for understanding immunotherapy response

T LaSalle, EE Austin, G Rigney… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Cancer immunotherapy research is expanding to include a more robust
understanding of the mechanisms of treatment response and resistance. Identification of …

Non-invasive detection of immunotherapy-induced adverse events

CA Ferreira, P Heidari, B Ataeinia, N Sinevici… - Clinical Cancer …, 2021 - AACR
Purpose: Cancer immunotherapy has markedly improved the prognosis of patients with a
broad variety of malignancies. However, benefits are weighed against unique toxicities, with …

Impact on renal function of percutaneous thermal ablation of renal masses in patients with preexisting chronic kidney disease

E Wehrenberg-Klee, TWI Clark, SB Malkowicz… - Journal of Vascular and …, 2012 - Elsevier
PURPOSE: To examine the effect of percutaneous thermal ablation of renal masses on renal
function among patients with baseline chronic kidney disease (CKD). MATERIALS AND …