Highlights•Oncolytic viruses (OVs) can modulate tumour microenvironment (TME) towards
less immunosuppressive phenotype and induce anti-cancer immunity.•OVs can be used as …

This paper describes the characterization of an intracellular β-glucosidase enzyme BGLII
(Cel1a) and its gene (bgl2) from the cellulolytic fungus Trichoderma reesei (Hypocrea …

Virus-based cancer vaccines are nowadays considered an interesting approach in the field
of cancer immunotherapy, despite the observation that the majority of the immune responses …

MicroRNAs have emerged as important players in tissue-specific mammalian gene
regulation and have also been exploited in experimental targeting of gene expression. We …

Because of the high coverage of international vaccination programs, most people worldwide
have been vaccinated against common pathogens, leading to acquired pathogen-specific …

Besides the isolation and identification of major histocompatibility complex I-restricted
peptides from the surface of cancer cells, one of the challenges is eliciting an effective …

Background Despite the success of immune checkpoint inhibitors against PD-L1 in the
clinic, only a fraction of patients benefit from such therapy. A theoretical strategy to increase …

The approval of the first oncolytic virus for the treatment of metastatic melanoma and the
compiling evidence that the use of oncolytic viruses can enhance cancer immunotherapies …

Molecular mimicry is one of the leading mechanisms by which infectious agents can induce
autoimmunity. Whether a similar mechanism triggers an antitumor immune response is …

Artificial target sequences for tissue-specific miRNAs have recently been introduced as a
new means for altering the tissue tropism of viral replication. This approach can be used to …