Regulation of gene expression by hypertonicity

MB Burg, ED Kwon, D KÜltz - Annual Review of Physiology, 1997 - annualreviews.org
▪ Abstract Adaptation of cells to hypertonicity often involves changes in gene expression.
Since the concentration of salt in the interstitial fluid surrounding renal inner medullary cells …

Implications of B7-H1 expression in clear cell carcinoma of the kidney for prognostication and therapy

RH Thompson, H Dong, ED Kwon - Clinical Cancer Research, 2007 - AACR
B7-H1 encompasses a recently discovered cell surface glycoprotein within the B7 family of T-
cell coregulatory molecules. B7-H1 expression can be induced on activated T lymphocytes …

[HTML][HTML] Prostate cancer–specific PET radiotracers: A review on the clinical utility in recurrent disease

JD Evans, KR Jethwa, P Ost, S Williams… - Practical radiation …, 2018 - Elsevier
Prostate cancer–specific positron emission tomography (pcPET) has been shown to detect
sites of disease recurrence at serum prostate-specific antigen (PSA) levels that are lower …

Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy …

ED Kwon, CG Drake, HI Scher, K Fizazi, A Bossi… - The lancet …, 2014 - thelancet.com
Background Ipilimumab is a fully human monoclonal antibody that binds cytotoxic T-
lymphocyte antigen 4 to enhance antitumour immunity. Our aim was to assess the use of …

Clinical significance of defective dendritic cell differentiation in cancer

B Almand, JR Resser, B Lindman, S Nadaf… - Clinical Cancer …, 2000 - AACR
Defective dendritic cell (DC) function has been described previously in cancer patients and
tumor-bearing mice. It can be an important factor in the escape of tumors from immune …

Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target

RH Thompson, MD Gillett, JC Cheville… - Proceedings of the …, 2004 - National Acad Sciences
Expression of B7-H1, a costimulating glycoprotein in the B7 family, is normally restricted to
macrophage-lineage cells, providing a potential costimulatory signal source for regulation of …

Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up

RH Thompson, SM Kuntz, BC Leibovich, H Dong… - Cancer research, 2006 - AACR
Abstract B7-H1 participates in T-cell costimulation functioning as a negative regulator of
immunity. Recent observations suggest that B7-H1 is expressed by renal cell carcinoma …

Prediction of progression after radical nephrectomy for patients with clear cell renal cell carcinoma: a stratification tool for prospective clinical trials

BC Leibovich, ML Blute, JC Cheville… - … Journal of the …, 2003 - Wiley Online Library
BACKGROUND The objective of the current study was to develop an algorithm to predict
progression to metastases after radical nephrectomy for patients with clinically localized …

Radical nephrectomy for pT1a renal masses may be associated with decreased overall survival compared with partial nephrectomy

RH Thompson, SA Boorjian, CM Lohse… - The Journal of …, 2008 - auajournals.org
Purpose: We reviewed our surgical experience with small renal tumors, comparing overall
survival in patients treated with radical and partial nephrectomy. Materials and Methods …

[PDF][PDF] Randomized, double-blind, phase III trial of ipilimumab versus placebo in asymptomatic or minimally symptomatic patients with metastatic chemotherapy-naive …

TM Beer, ED Kwon, CG Drake, K Fizazi, C Logothetis… - J Clin …, 2017 - dr-carvajal.com
Purpose Ipilimumab increases antitumor T-cell responses by binding to cytotoxic T-
lymphocyte antigen 4. We evaluated treatment with ipilimumab in asymptomatic or minimally …