The miR-124-Sox9 paramutation: RNA-mediated epigenetic control of embryonic and adult growth

V Grandjean, P Gounon, N Wagner, L Martin… - …, 2009 - journals.biologists.com
The size of the mammalian body is determined by genetic and environmental factors
differentially modulating pre-and postnatal growth. We now report a control of growth acting …

[PDF][PDF] MCM8-and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination

M Lutzmann, C Grey, S Traver, O Ganier… - Molecular cell, 2012 - cell.com
We generated knockout mice for MCM8 and MCM9 and show that deficiency for these
genes impairs homologous recombination (HR)-mediated DNA repair during …

Development of the malaria parasite in the skin of the mammalian host

P Gueirard, J Tavares, S Thiberge… - Proceedings of the …, 2010 - National Acad Sciences
The first step of Plasmodium development in vertebrates is the transformation of the
sporozoite, the parasite stage injected by the mosquito in the skin, into merozoites, the stage …

Spatial and temporal patterns of c-kit-expressing cells in WlacZ/+ and WlacZ/WlacZ mouse embryos

F Bernex, PD Sepulveda, C Kress, C Elbaz… - …, 1996 - journals.biologists.com
In the mouse, the Kit receptor and its ligand, the stem cell factor (SCF), are encoded at the
W/Kit and Steel loci, respectively. The Kit/SCF transduction pathway is involved in promoting …

A canine Arylsulfatase G (ARSG) mutation leading to a sulfatase deficiency is associated with neuronal ceroid lipofuscinosis

M Abitbol, JL Thibaud, NJ Olby… - Proceedings of the …, 2010 - National Acad Sciences
Neuronal ceroid lipofuscinoses (NCLs) represent the most common group of inherited
progressive encephalopathies in children. They are characterized by progressive loss of …

Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesis

K Mrouj, N Andrés-Sánchez, G Dubra… - Proceedings of the …, 2021 - National Acad Sciences
Ki-67 is a nuclear protein that is expressed in all proliferating vertebrate cells. Here, we
demonstrate that, although Ki-67 is not required for cell proliferation, its genetic ablation …

[HTML][HTML] Preclinical validation of AXL receptor as a target for antibody-based pancreatic cancer immunotherapy

W Leconet, C Larbouret, T Chardès, G Thomas… - Oncogene, 2014 - nature.com
AXL receptor tyrosine kinase (RTK) is implicated in proliferation and invasion of many
cancers, particularly in pancreatic ductal adenocarcinoma (PDAC), for which new …

Cross talk between Paneth and tuft cells drives dysbiosis and inflammation in the gut mucosa

N Coutry, J Nguyen, S Soualhi… - Proceedings of the …, 2023 - National Acad Sciences
Gut microbiota imbalance (dysbiosis) is increasingly associated with pathological
conditions, both within and outside the gastrointestinal tract. Intestinal Paneth cells are …

[PDF][PDF] Mitochondrial MDM2 regulates respiratory complex I activity independently of p53

G Arena, MY Cissé, S Pyrdziak, L Chatre, R Riscal… - Molecular cell, 2018 - cell.com
Accumulating evidence indicates that the MDM2 oncoprotein promotes tumorigenesis
beyond its canonical negative effects on the p53 tumor suppressor, but these p53 …

Cancer prevalence and etiology in wild and captive animals

T Madsen, A Arnal, M Vittecoq, F Bernex… - Ecology and evolution of …, 2017 - Elsevier
Neoplasia has been recorded in the vast majority of metazoans. The frequent occurrence of
cancer in multicellular organisms suggests that neoplasia, similar to pathogens/parasites …