Accumulating evidence indicates that the innate and adaptive immune systems make a
crucial contribution to the antitumour effects of conventional chemotherapy-based and …

Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …

For the last four decades, the treatment of cancer has relied on four treatment modalities,
namely surgery, radiotherapy, cytotoxic chemotherapy, and hormonotherapy. Most of these …

Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis induce sustained clinical
responses in a sizable minority of cancer patients. We found that primary resistance to ICIs …

Abstract CD4+ CD25+ regulatory T cells are involved in the prevention of autoimmune
diseases and in tumor-induced tolerance. We previously demonstrated in tumor-bearing …

Tumor growth promotes the expansion of CD4+ CD25+ regulatory T (T reg) cells that
counteract T cell–mediated immune responses. An inverse correlation between natural killer …

Conventional cancer treatments rely on radiotherapy and chemotherapy. Such treatments
supposedly mediate their effects via the direct elimination of tumor cells. Here we show that …

Anthracyclin-treated tumor cells are particularly effective in eliciting an anticancer immune
response, whereas other DNA-damaging agents such as etoposide and mitomycin C do not …

Myeloid-derived suppressor cells (MDSC) accumulate in the spleen and tumor bed during
tumor growth. They contribute to the immune tolerance of cancer notably by inhibiting the …

The therapeutic efficacy of anticancer chemotherapies may depend on dendritic cells (DCs),
which present antigens from dying cancer cells to prime tumor-specific interferon-γ (IFN-γ) …