User profiles for "author:Francesca Ascenzi"

Francesca Ascenzi

sapienza
Verified email at uniroma1.it
Cited by 353

[HTML][HTML] SCD1, autophagy and cancer: implications for therapy

F Ascenzi, C De Vitis, M Maugeri-Saccà… - Journal of Experimental …, 2021 - Springer
Background Autophagy is an intracellular degradation system that removes unnecessary or
dysfunctional components and recycles them for other cellular functions. Over the years, a …

Effects of IGF‐1 isoforms on muscle growth and sarcopenia

F Ascenzi, L Barberi, G Dobrowolny… - Aging cell, 2019 - Wiley Online Library
The decline in skeletal muscle mass and strength occurring in aging, referred as sarcopenia,
is the result of many factors including an imbalance between protein synthesis and …

[HTML][HTML] ALDOC-and ENO2-driven glucose metabolism sustains 3D tumor spheroids growth regardless of nutrient environmental conditions: a multi-omics analysis

C De Vitis, AM Battaglia, M Pallocca… - Journal of Experimental …, 2023 - Springer
Background Metastases are the major cause of cancer-related morbidity and mortality. By
the time cancer cells detach from their primary site to eventually spread to distant sites, they …

[HTML][HTML] Sustained systemic levels of IL-6 impinge early muscle growth and induce muscle atrophy and wasting in adulthood

L Pelosi, MG Berardinelli, L Forcina, F Ascenzi… - Cells, 2021 - mdpi.com
IL-6 is a pleiotropic cytokine that can exert different and opposite effects. The muscle-
induced and transient expression of IL-6 can act in an autocrine or paracrine manner …

Skeletal muscle myopenia in mice model of bile duct ligation and carbon tetrachloride‐induced liver cirrhosis

M Giusto, L Barberi, F Di Sario, E Rizzuto… - Physiological …, 2017 - Wiley Online Library
Skeletal muscle myopathy is universal in cirrhotic patients, however, little is known about the
main mechanisms involved. The study aims to investigate skeletal muscle morphological …

[HTML][HTML] IL-10, IL-13, Eotaxin and IL-10/IL-6 ratio distinguish breast implant-associated anaplastic large-cell lymphoma from all types of benign late seromas

A Di Napoli, D Greco, G Scafetta, F Ascenzi… - Cancer Immunology …, 2021 - Springer
Breast implant-associated anaplastic large-cell lymphoma (BI-ALCL) is an uncommon
peripheral T cell lymphoma usually presenting as a delayed peri-implant effusion. Chronic …

[HTML][HTML] Deconvolution of malignant pleural effusions immune landscape unravels a novel macrophage signature associated with worse clinical outcome in lung …

S Bruschini, M Pallocca, E Sperandio… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Immune checkpoint inhibitors are still unable to provide clinical benefit to the
large majority of non-small cell lung cancer (NSCLC) patients. A deeper characterization of …

[HTML][HTML] B4GALT1 as a New Biomarker of Idiopathic Pulmonary Fibrosis

C De Vitis, M D'Ascanio, A Sacconi… - International Journal of …, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a disease characterized by progressive scarring of the
lung that involves the pulmonary interstitium. The disease may rapidly progress, leading to …

[HTML][HTML] B4GALT1 is a new candidate to maintain the stemness of lung cancer stem cells

C De Vitis, G Corleone, V Salvati, F Ascenzi… - Journal of Clinical …, 2019 - mdpi.com
Background: According to the cancer stem cells (CSCs) hypothesis, a population of cancer
cells with stem cell properties is responsible for tumor propagation, drug resistance, and …

Identification of a set of genes potentially responsible for resistance to ferroptosis in lung adenocarcinoma cancer stem cells

R Mancini, F Ascenzi, A Esposito, S Bruschini, V Salvati… - 2023 - researchsquare.com
Scientific literature supports the evidence that Cancer Stem Cells (CSCs) retain inside low
Reactive Oxygen Species (ROS) levels and are therefore less susceptible to cell death …