[HTML][HTML] Safety of immune checkpoint inhibitor rechallenge after discontinuation for grade≥ 2 immune-related adverse events in patients with cancer

M Allouchery, T Lombard, M Martin… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Safety of rechallenge of immune checkpoint inhibitor (ICI) after grade≥ 2
immune-related adverse events (irAEs) leading to ICI discontinuation remains unclear …

Artificial intelligence for unstructured healthcare data: application to coding of patient reporting of adverse drug reactions

L Létinier, J Jouganous, M Benkebil… - Clinical …, 2021 - Wiley Online Library
Adverse drug reaction (ADR) reporting is a major component of drug safety monitoring; its
input will, however, only be optimized if systems can manage to deal with its tremendous …

[HTML][HTML] Immune check point inhibitors-induced hypophysitis: a retrospective analysis of the French pharmacovigilance database

J Garon-Czmil, N Petitpain, F Rouby, M Sassier… - Scientific reports, 2019 - nature.com
Immune control point (ICI) inhibitors represent a significant advance in the management and
survival of cancers such as melanoma or non-small cell bronchial carcinoma. However, they …

Acute coronary syndrome with immune checkpoint inhibitors: a proof-of-concept case and pharmacovigilance analysis of a life-threatening adverse event

J Cautela, F Rouby, JE Salem, J Alexandre… - Canadian Journal of …, 2020 - Elsevier
Isolated cases of acute coronary syndrome (ACS) associated with immune checkpoint
inhibitors (ICIs) have been described without the establishment of a formal cause-and-effect …

Thrombotic microangiopathy associated with gemcitabine use: Presentation and outcome in a national French retrospective cohort

F Daviet, F Rouby, P Poullin… - British journal of …, 2019 - Wiley Online Library
Aims Gemcitabine has been associated with thrombotic microangiopathy (TMA). We
conducted a national retrospective study of gemcitabine‐associated TMA (G‐TMA). Methods …

Occurrence of type 1 and type 2 diabetes in patients treated with immunotherapy (anti-PD-1 and/or anti-CTLA-4) for metastatic melanoma: a retrospective study

ML Gauci, P Boudou, B Baroudjian… - Cancer Immunology …, 2018 - Springer
Abstract Anti-PD-1 and anti-CTLA-4 antibodies cause immune-related side effects such as
autoimmune type 1 diabetes (T1D). It has also been suggested that by increasing TNF-α, IL …

[HTML][HTML] Immune checkpoint inhibitor-related cytopenias: about 68 cases from the French Pharmacovigilance Database

M Martin, HM Nguyen, C Beuvon, J Bene, P Palassin… - Cancers, 2022 - mdpi.com
Simple Summary Data on immune checkpoint inhibitor (ICI)-related cytopenias are scarce.
The aim of the study was to further characterize grade≥ 2 ICI-related cytopenias using the …

Brain networks are independently modulated by donepezil, sleep, and sleep deprivation

J Wirsich, M Rey, M Guye, C Bénar, L Lanteaume… - Brain topography, 2018 - Springer
Resting-state connectivity has been widely studied in the healthy and pathological brain.
Less well-characterized are the brain networks altered during pharmacological interventions …

Proton pump inhibitors prescriptions in France: Main trends from 2006 to 2016 on French health insurance database

Q Boucherie, F Rouby, D Frankel, P Roll, J Micallef - Therapies, 2018 - Elsevier
Because national data on proton pump inbibitors (PPIs) consumption in France are scarce
and because there is a growing literature on potential adverse drug reaction induced by this …

Thyroiditis and immune check point inhibitors: the post‐marketing experience using the French National Pharmacovigilance database

J Garon‐Czmil, N Petitpain, F Rouby… - Fundamental & …, 2019 - Wiley Online Library
Immunotherapy with immune checkpoint inhibitors (ICI s) for cancer has become
increasingly prescribed in recent years. Indeed, it is used to treat both solid and …