Peutz–Jeghers syndrome (PJS, MIM175200) is an autosomal dominant condition defined by
the development of characteristic polyps throughout the gastrointestinal tract and …

Lynch syndrome (hereditary non-polyposis colorectal cancer) is characterised by the
development of colorectal cancer, endometrial cancer and various other cancers, and is …

The landscape of cancer treatment has dramatically changed over the last four decades.
The age when surgery and radiotherapy were the only effective way to fight tumour growth …

Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial
cancer and various other cancers, and is caused by a mutation in one of the mismatch repair …

Background: Familial adenomatous polyposis (FAP) is a well-described inherited syndrome,
which is responsible for< 1% of all colorectal cancer (CRC) cases. The syndrome is …

Germ-line mutations in the tumor suppressor gene APC are associated with hereditary
familial adenomatous polyposis (FAP), and somatic mutations are common in sporadic …

In a genome-wide association study to identify loci associated with colorectal cancer (CRC)
risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 …

Abstract O 6-Methylguanine DNA methyltransferase (MGMT) is a DNA repair protein that
removes mutagenic and cytotoxic adducts from the O 6 position of guanine. O 6 …

Gene Expression Signature to Improve Prognosis Prediction of Stage II and III Colorectal
Cancer Page 1 Gene Expression Signature to Improve Prognosis Prediction of Stage II and III …

The INK4a/ARF locus encodes two cell cycle-regulatory proteins, p16 INK4a and p14 ARF,
which share an exon using different reading frames. p14 ARF antagonizes MDM2 …