Tumor cells are continually subjected to diverse stress conditions of the tumor
microenvironment, including hypoxia, nutrient deprivation, and oxidative or genotoxic stress …

Glucose is a major requirement for biological life. Its concentration is constantly sensed at
the cellular level, allowing for adequate responses to any changes of glucose availability …

The RAS family of proto-oncogenes comprises HRAS, KRAS, and NRAS, which are among
the most mutated genes in human cancers. The RAS family genes encode small GTPases …

Metabolic adaptation is essential for cell survival during nutrient deprivation. We report that
eukaryotic elongation factor 2 kinase (eEF2K), which is activated by AMP-kinase (AMPK) …

Metastatic dissemination is the leading cause of death in cancer patients, which is
particularly evident for high-risk sarcomas such as Ewing sarcoma, osteosarcoma, and …

Under cell stress, global protein synthesis is inhibited to preserve energy. One mechanism is
to sequester and silence mRNAs in ribonucleoprotein complexes known as stress granules …

The RAS family of proto-oncogenes are among the most commonly mutated genes in
human cancers and predict poor clinical outcome. Several mechanisms underlying …

Oncogenic KRAS is the key driver oncogene for several of the most aggressive human
cancers. One key feature of oncogenic KRAS expression is an early increase in cellular …

Glioblastoma multiform (GBM) is the most common brain tumor characterized by a dismal
prognosis. GBM cancer stem cells (gCSC) or tumor-initiating cells are the cell population …

Oxidative stress plays a key role in late onset diseases including cancer and
neurodegenerative diseases such as Huntington disease. Therefore, uncovering regulators …