By using human melanoma and glioblastoma cell lines and their derivative BCL-XL
overexpressing clones, we investigated the role of BCL-XL in aggressive features of these …

Background Lung cancer represents the most frequent cause of death for cancer. In non-
small cell lung cancer (NSCLC), which accounts for the vast majority of this disease, only …

BACKGROUND: The number of resected lymph-nodes (# RNs) has proven prognostic in
breast and colorectal cancer. Here we evaluated its prognostic impact in a series of resected …

Long non-coding RNAs are emerging as new molecular players involved in many biological
processes, such as proliferation, apoptosis, cell cycle, migration, and differentiation. Their …

Background This study assessed perioperative outcome and long-term survival in a large
series of patients with malignant pleural mesothelioma who underwent extrapleural …

Results An 82-year-old woman was diagnosed in 2018 with invasive ductal carcinoma (IDC)
of the right breast, grade 3, ER-/PR-/HER2 3+, that had metastasized to the lymph nodes …

Background Mutations in the TP53 (Tumour Protein 53) gene can lead to expression of
mutant p53 proteins that accumulate in cancer cells and can induce circulating p53 …

Cancer stem cells (CSCs) are a subpopulation with the properties of extensive self‐renewal,
capability to generate differentiated cancer cells and resistance to therapies. We have …

Risk assessment and treatment choice remain a challenge in early non-small-cell lung
cancer (NSCLC). Alternative splicing is an emerging source for diagnostic, prognostic and …

Objectives Tumor angiogenesis is an essential and complex process necessary for the
growth of all tumors which represents a potential therapeutic target. Angiogenesis inhibitors …