User profiles for "author:George Coukos"
George CoukosUniversity Hospital of Lausanne, Ludwig Institute for Cancer Research Verified email at chuv.ch Cited by 80970 |
Cancer immunotherapy comes of age
Activating the immune system for therapeutic benefit in cancer has long been a goal in
immunology and oncology. After decades of disappointment, the tide has finally changed …
immunology and oncology. After decades of disappointment, the tide has finally changed …
Rethinking ovarian cancer: recommendations for improving outcomes
S Vaughan, JI Coward, RC Bast Jr, A Berchuck… - Nature Reviews …, 2011 - nature.com
There have been major advances in our understanding of the cellular and molecular biology
of the human malignancies that are collectively referred to as ovarian cancer. At a recent …
of the human malignancies that are collectively referred to as ovarian cancer. At a recent …
Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer
DD Bowtell, S Böhm, AA Ahmed, PJ Aspuria… - Nature reviews …, 2015 - nature.com
High-grade serous ovarian cancer (HGSOC) accounts for 70–80% of ovarian cancer deaths,
and overall survival has not changed significantly for several decades. In this Opinion article …
and overall survival has not changed significantly for several decades. In this Opinion article …
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
Regulatory T (Treg) cells mediate homeostatic peripheral tolerance by suppressing
autoreactive T cells. Failure of host antitumor immunity may be caused by exaggerated …
autoreactive T cells. Failure of host antitumor immunity may be caused by exaggerated …
[HTML][HTML] Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
L Zhang, JR Conejo-Garcia, D Katsaros… - New England journal …, 2003 - Mass Medical Soc
Background Although tumor-infiltrating T cells have been documented in ovarian carcinoma,
a clear association with clinical outcome has not been established. Methods We performed …
a clear association with clinical outcome has not been established. Methods We performed …
microRNAs exhibit high frequency genomic alterations in human cancer
L Zhang, J Huang, N Yang… - Proceedings of the …, 2006 - National Acad Sciences
MicroRNAs (miRNAs) are endogenous noncoding RNAs, which negatively regulate gene
expression. To determine genomewide miRNA DNA copy number abnormalities in cancer …
expression. To determine genomewide miRNA DNA copy number abnormalities in cancer …
Regulatory CD4+CD25+ T Cells in Tumors from Patients with Early-Stage Non-Small Cell Lung Cancer and Late-Stage Ovarian Cancer
EY Woo, CS Chu, TJ Goletz, K Schlienger, H Yeh… - Cancer research, 2001 - AACR
Immunosuppression may contribute to the progression of cancer. In this study we assessed
the structural and functional status of T cells from tumor specimens obtained from patients …
the structural and functional status of T cells from tumor specimens obtained from patients …
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
A Facciabene, X Peng, IS Hagemann, K Balint… - Nature, 2011 - nature.com
Although immune mechanisms can suppress tumour growth,, tumours establish potent,
overlapping mechanisms that mediate immune evasion,,,. Emerging evidence suggests a …
overlapping mechanisms that mediate immune evasion,,,. Emerging evidence suggests a …
The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis
Q Huang, K Gumireddy, M Schrier, C Le Sage… - Nature cell …, 2008 - nature.com
MicroRNAs (miRNAs) are single-stranded, noncoding RNAs that are important in many
biological processes,. Although the oncogenic and tumour-suppressive functions of several …
biological processes,. Although the oncogenic and tumour-suppressive functions of several …
Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer
MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs that function as
negative gene regulators. miRNA deregulation is involved in the initiation and progression …
negative gene regulators. miRNA deregulation is involved in the initiation and progression …