User profiles for "author:George Coukos"

George Coukos

University Hospital of Lausanne, Ludwig Institute for Cancer Research
Verified email at chuv.ch
Cited by 80970

Cancer immunotherapy comes of age

I Mellman, G Coukos, G Dranoff - Nature, 2011 - nature.com
Activating the immune system for therapeutic benefit in cancer has long been a goal in
immunology and oncology. After decades of disappointment, the tide has finally changed …

Rethinking ovarian cancer: recommendations for improving outcomes

S Vaughan, JI Coward, RC Bast Jr, A Berchuck… - Nature Reviews …, 2011 - nature.com
There have been major advances in our understanding of the cellular and molecular biology
of the human malignancies that are collectively referred to as ovarian cancer. At a recent …

Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

DD Bowtell, S Böhm, AA Ahmed, PJ Aspuria… - Nature reviews …, 2015 - nature.com
High-grade serous ovarian cancer (HGSOC) accounts for 70–80% of ovarian cancer deaths,
and overall survival has not changed significantly for several decades. In this Opinion article …

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

TJ Curiel, G Coukos, L Zou, X Alvarez, P Cheng… - Nature medicine, 2004 - nature.com
Regulatory T (Treg) cells mediate homeostatic peripheral tolerance by suppressing
autoreactive T cells. Failure of host antitumor immunity may be caused by exaggerated …

[HTML][HTML] Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer

L Zhang, JR Conejo-Garcia, D Katsaros… - New England journal …, 2003 - Mass Medical Soc
Background Although tumor-infiltrating T cells have been documented in ovarian carcinoma,
a clear association with clinical outcome has not been established. Methods We performed …

microRNAs exhibit high frequency genomic alterations in human cancer

L Zhang, J Huang, N Yang… - Proceedings of the …, 2006 - National Acad Sciences
MicroRNAs (miRNAs) are endogenous noncoding RNAs, which negatively regulate gene
expression. To determine genomewide miRNA DNA copy number abnormalities in cancer …

Regulatory CD4+CD25+ T Cells in Tumors from Patients with Early-Stage Non-Small Cell Lung Cancer and Late-Stage Ovarian Cancer

EY Woo, CS Chu, TJ Goletz, K Schlienger, H Yeh… - Cancer research, 2001 - AACR
Immunosuppression may contribute to the progression of cancer. In this study we assessed
the structural and functional status of T cells from tumor specimens obtained from patients …

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

A Facciabene, X Peng, IS Hagemann, K Balint… - Nature, 2011 - nature.com
Although immune mechanisms can suppress tumour growth,, tumours establish potent,
overlapping mechanisms that mediate immune evasion,,,. Emerging evidence suggests a …

The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis

Q Huang, K Gumireddy, M Schrier, C Le Sage… - Nature cell …, 2008 - nature.com
MicroRNAs (miRNAs) are single-stranded, noncoding RNAs that are important in many
biological processes,. Although the oncogenic and tumour-suppressive functions of several …

Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer

L Zhang, S Volinia, T Bonome… - Proceedings of the …, 2008 - National Acad Sciences
MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs that function as
negative gene regulators. miRNA deregulation is involved in the initiation and progression …