Over the past years the number of medical registries has increased sharply. Their value
strongly depends on the quality of the data contained in the registry. To optimize data …

Background Laparoscopic surgery has several advantages when compared to open
surgery, including faster postoperative recovery and lower pain scores. However, for …

Danger-associated molecular patterns (DAMPs) that are released by injured, threatened, or
dead cells, or that originate from the extracellular matrix, influence the immune system. This …

Chronic pain is common and undesirable after surgery. Progression from acute to chronic
pain involves altered pain processing. The authors studied relationships between presence …

BACKGROUND The practice of anaesthesia comes with stress. If the demands of a stressful
job exceed the resources of an individual, that person may develop burnout. Burnout poses …

Purpose Danger-associated molecular patterns (DAMPs) released of trauma could
contribute to an immune suppressed state that renders patients vulnerable towards …

Background Mechanical ventilation (MV) may activate the innate immune system, causing
the release of cytokines. The resulting proinflammatory state is a risk factor for ventilator …

Objective. To analyse the quality of data used to measure severity of illness in the Dutch
National Intensive Care Evaluation (NICE) registry, after implementation of quality improving …

Background Mechanical ventilation (MV) can induce ventilator-induced lung injury. A role for
proinflammatory pathways has been proposed. The current studies analyzed the roles of …

Background Hyperalgesia is a well recognized hallmark of disease. Pro-inflammatory
cytokines have been suggested to be mainly responsible, but human data are scarce …