Traditional treatment modalities for advanced cancer (radiotherapy, chemotherapy, or
targeted agents) act directly on tumors to inhibit or destroy them. Along with surgery, these …

Background Treatment with doxorubicin is a present standard of care for patients with
metastatic soft-tissue sarcoma and median overall survival for those treated is 12–16 …

Advanced melanoma has defied treatment advances for several decades. Immunotherapy
with high-dose interleukin-2 or interferon-α has been beneficial in some cases, but …

The N-terminal region of the gene encoding polyhedrin, the major occlusion protein of the
insect baculovirus Autographa californica nuclear polyhedrosis virus (AcNPV), has been …

Abstract Treatment outcomes have improved with the advent of immune checkpoint
inhibitors and small molecule inhibitors. However, many patients do not respond with single …

Background The left atrium (LA) is usually enlarged in patients with nonvalvular atrial
fibrillation (AF), but factors associated with LA diameter are incompletely defined. Methods …

Aside from its more conventional uses as a cardiovascular drug, the calcium channel
blocker verapamil has recently been added to chemotherapeutic regimens to reduce drug …

We analyzed transesophageal echocardiograms from 772 participants in the Stroke
Prevention in Atrial Fibrillation (SPAF-III) study, characterizing spontaneous …

Background Anti-programmed cell death ligand 1 (PD-L1)/programmed cell death 1
antibodies have shown clinical activity in platinum-treated metastatic urothelial carcinoma …

Thyroid hormone exerts a strong positive inotropic action on the heart and induces a-myosin
heavy chain (MHC) gene expression. 3, 5-Diiodothyropropionic acid (DITPA), a carboxylic …