[HTML][HTML] Head-to-head comparison of in-house produced CD19 CAR-T cell in ALL and NHL patients
Background CD19 chimeric antigen receptor T (CAR-T) cells demonstrate remarkable
remission rates in pediatric and adult patients with refractory or relapsed (r/r) acute …
remission rates in pediatric and adult patients with refractory or relapsed (r/r) acute …
[HTML][HTML] Automated production of gene-modified chimeric antigen receptor T cells using the Cocoon Platform
N Trainor, KA Purpura, K Middleton, K Fargo, L Hails… - Cytotherapy, 2023 - Elsevier
Autologous cell-based therapeutics have gained increasing attention in recent years
because of their efficacy at treating diseases with limited therapeutic options. Chimeric …
because of their efficacy at treating diseases with limited therapeutic options. Chimeric …
[HTML][HTML] Continuous inflammatory stimulation leads via metabolic plasticity to a prometastatic phenotype in triple-negative breast cancer cells
D Morein, L Rubinstein-Achiasaf, H Brayer, O Dorot… - Cells, 2021 - mdpi.com
Chronic inflammation promotes cancer progression by affecting the tumor cells and their
microenvironment. Here, we demonstrate that a continuous stimulation (~ 6 weeks) of triple …
microenvironment. Here, we demonstrate that a continuous stimulation (~ 6 weeks) of triple …
[HTML][HTML] Genetic Modification of Tumor-Infiltrating Lymphocytes via Retroviral Transduction
H Weinstein-Marom, G Gross, M Levi, H Brayer… - Frontiers in …, 2021 - frontiersin.org
Adoptive T cell therapy (ACT) holds great promise for cancer treatment. One approach,
which has regained wide interest in recent years, employs antitumor T cells isolated from …
which has regained wide interest in recent years, employs antitumor T cells isolated from …
[CITATION][C] Gammaretroviral Vector CD19 CAR-T Manufactured in the Cocoon (R) Platform: An Automated and Closed Workflow
KA Purpura, RG Malka… - MOLECULAR …, 2021 - CELL PRESS 50 HAMPSHIRE ST …