[HTML][HTML] Pyrroline-5-Carboxylate Reductase 1: a novel target for sensitizing multiple myeloma cells to bortezomib by inhibition of PRAS40-mediated protein synthesis

I Oudaert, H Satilmis, P Vlummens… - Journal of Experimental …, 2022 - Springer
Background Multiple myeloma (MM) remains an incurable cancer despite advances in
therapy. Therefore, the search for new targets is still essential to uncover potential treatment …

Metformin confers sensitisation to syrosingopine in multiple myeloma cells by metabolic blockage and inhibition of protein synthesis

A Van der Vreken, I Oudaert, G Ates… - The Journal of …, 2023 - Wiley Online Library
Multiple myeloma (MM) remains an incurable haematological malignancy despite
substantial advances in therapy. Hypoxic bone marrow induces metabolic rewiring in MM …

Targeting the β2‐adrenergic receptor increases chemosensitivity in multiple myeloma by induction of apoptosis and modulating cancer cell metabolism

H Satilmis, E Verheye, P Vlummens… - The Journal of …, 2023 - Wiley Online Library
While multi‐drug combinations and continuous treatment have become standard for multiple
myeloma, the disease remains incurable. Repurposing drugs that are currently used for …

[HTML][HTML] Targeting S100A9 protein affects mTOR-ER stress signaling and increases venetoclax sensitivity in Acute Myeloid Leukemia

R Fan, H Satilmis, N Vandewalle, E Verheye… - Blood Cancer …, 2023 - nature.com
Abstract Acute Myeloid Leukemia (AML) is a heterogeneous disease with limited treatment
options and a high demand for novel targeted therapies. Since myeloid-related protein …

[HTML][HTML] Tasquinimod suppresses tumor cell growth and bone resorption by targeting immunosuppressive myeloid cells and inhibiting c-MYC expression in multiple …

R Fan, H Satilmis, N Vandewalle… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Immunotherapy emerged as a promising treatment option for multiple myeloma
(MM) patients. However, therapeutic efficacy can be hampered by the presence of an …

[HTML][HTML] Tasquinimod targets immunosuppressive myeloid cells, increases osteogenesis and has direct anti-myeloma effects by inhibiting c-myc expression in vitro …

R Fan, H Satilmis, N Vandewalle, E De Bruyne, E Menu… - Blood, 2021 - Elsevier
Introduction Immunotherapy has revolutionized cancer treatment and significantly affected
the management of Multiple Myeloma (MM) patients. Unfortunately, these …

Inhibition of Oxidative Phosphorylation and Glycolysis Reduces Viability in Multiple Myeloma By Affecting mTOR-Mediated Protein Synthesis

I Oudaert, A Van der Vreken, G Ates, S Faict… - Blood, 2022 - ashpublications.org
Multiple myeloma (MM) remains an incurable cancer despite advances in therapy. Currently,
MM patients are treated with combinations of multiple drugs, although drug resistance …

AXL-specific single domain antibodies show diagnostic potential and anti-tumor activity in acute myeloid leukemia

N Vandewalle, H Satilmis, EM Verheye, R Fan, Y Wang… - Cancer Research, 2024 - AACR
Rationale: AXL expression has been identified as a prognostic factor in acute myeloid
leukemia (AML) and is detectable in approximately 50% of AML patients. In this study, we …

PYCR1 inhibition in multiple myeloma-associated stroma limits tumor growth

I Oudaert, C Muylaert, H Satilmis, S Faict… - Cancer Research, 2023 - AACR
Introduction Multiple myeloma (MM) is a hematological cancer, characterized by the
accumulation of monoclonal plasma cells in the bone marrow. It remains an incurable …

[HTML][HTML] Pyrroline-5-Carboxylate Reductase 1: A Novel Target for Sensitizing Myeloma to Cytotoxic Agents By Inhibition of PRAS40-Mediated Protein Synthesis

I Oudaert, H Satilmis, P Vlummens, A Maes… - Blood, 2021 - Elsevier
Introduction Multiple myeloma (MM) remains an incurable cancer despite advances in
therapy. Therefore, the search for new targets is still essential to uncover potential treatment …