NADPH oxidase 4 (Nox4) is constitutively active, while Nox2 requires the cytosolic
regulatory subunits p47 phox and p67 phox and activated Rac with activation by phorbol 12 …

In recent years, reactive oxygen species (ROS) derived from the vascular isoforms of
NADPH oxidase, Nox1, Nox2, and Nox4, have been implicated in many cardiovascular …

Purpose: Ipilimumab is a monoclonal antibody that blocks the immune-inhibitory interaction
between CTL antigen 4 (CTLA-4) and its ligands on T cells. Clinical trials in cancer patients …

The tumor antigen NY-ESO-1 is a promising cancer vaccine target. We describe here a
novel HLA-B7–restricted NY-ESO-1 epitope, encompassing amino acids 60-72 …

Nox5 belongs to the calcium-regulated subfamily of NADPH oxidases (Nox). Like other
calcium-regulated Noxes, Nox5 has an EF-hand-containing calcium-binding domain at its N …

Background To compare the clinical efficacy of New York Esophageal squamous cell
carcinoma-1 (NY-ESO-1) vaccine with ISCOMATRIX adjuvant versus ISCOMATRIX alone in …

Background NY-ESO-1 protein formulated in ISCOMATRIX™ results in CD4+, CD8+ T cell
and antibody-mediated immunity. We evaluated persistence of immunity, relapse-free …

By targeting redox-sensitive amino acids in signaling proteins, the NADPH oxidase (Nox)
family of enzymes link reactive oxygen species to physiological processes. We previously …

Holism is regarded as an effective means of alternative treatment, and there has been an
increase in the number of innovative holistic treatment interventions in diverse fields of …

Purpose This study examined the cognitive demands of 2 selection techniques in
augmentative and alternative communication (AAC), direct selection, and visual linear …