Heat shock proteins transfer peptides during antigen processing and CTL priming.

PK Srivastava, H Udono, NE Blachere, Z Li - Immunogenetics, 1994 - europepmc.org
Recently emerging evidence indicates that the heat shock proteins (HSPs) gp96, hsp90, and
hsp70 associate with antigenic peptides derived from cellular proteins. This evidence forms …

Metformin-ROS-Nrf2 connection in the host defense mechanism against oxidative stress, apoptosis, cancers, and ageing

H Udono, M Nishida - Biochimica et Biophysica Acta (BBA)-General …, 2022 - Elsevier
Reactive oxygen species (ROS) acts as a second messenger to trigger biological responses
in low concentrations, while it is implicated to be toxic to biomolecules in high …

Immune-mediated antitumor effect by type 2 diabetes drug, metformin

S Eikawa, M Nishida, S Mizukami… - Proceedings of the …, 2015 - National Acad Sciences
Metformin, a prescribed drug for type 2 diabetes, has been reported to have anti-cancer
effects; however, the underlying mechanism is poorly understood. Here we show that this …

Cellular requirements for tumor-specific immunity elicited by heat shock proteins: tumor rejection antigen gp96 primes CD8+ T cells in vivo.

H Udono, DL Levey… - Proceedings of the …, 1994 - National Acad Sciences
Purified preparations of 96-kDa heat shock proteins (gp96) have been previously shown to
elicit tumor-specific immunity to the tumor from which gp96 is obtained but not to …

[HTML][HTML] Nutrient condition in the microenvironment determines essential metabolisms of CD8+ T cells for enhanced IFNγ Production by metformin

R Chao, M Nishida, M Tokumasu, H Udono - Frontiers in immunology, 2022 - frontiersin.org
Metformin (Met), a first-line drug for type 2 diabetes, lowers blood glucose levels by
suppressing gluconeogenesis in the liver, presumably through the liver kinase B1 …

Heat shock protein 70-associated peptides elicit specific cancer immunity.

H Udono, PK Srivastava - The Journal of experimental medicine, 1993 - rupress.org
Vaccination of mice with heat shock protein 70 (hsp70) preparations derived from the Meth A
sarcoma, but not from normal tissues, renders the mice immune to a substantial challenge …

Heat shock protein–peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity

NE Blachere, Z Li, RY Chandawarkar, R Suto… - The Journal of …, 1997 - rupress.org
Heat shock protein (HSP) preparations derived from cancer cells and virus-infected cells
have been shown previously to elicit cancer-specific or virus-specific immunity. The …

Isolation of MHC class I-restricted tumor antigen peptide and its precursors associated with heat shock proteins hsp70, hsp90, and gp96

T Ishii, H Udono, T Yamano, H Ohta… - The Journal of …, 1999 - journals.aai.org
We have previously demonstrated that vaccination with heat shock proteins hsp70, hsp90,
and gp96 elicits specific immunity against the tumor from which the hsps were purified …

Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70.

H Udono, PK Srivastava - Journal of immunology (Baltimore, Md …, 1994 - journals.aai.org
Stress-induced proteins (or heat shock proteins (HSPs)) of 96 kDa size (gp96) have been
shown previously to elicit specific immunity to tumors from which they are isolated. In this …

Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects

T Uehara, S Eikawa, M Nishida… - International …, 2019 - academic.oup.com
CD11b+ myeloid subpopulations, including myeloid-derived suppressor cells (MDSCs) and
tumor-associated macrophages (TAMs), play crucial roles in the suppression of T-cell …