The tumor immune microenvironment contributes to tumor initiation, progression, and
response to therapy. Among the immune cell subsets that play a role in the tumor …

Solid tumors have a dynamic ecosystem in which malignant and non-malignant (endothelial,
stromal, and immune) cell types constantly interact. Importantly, the abundance, localization …

Immune checkpoint inhibitors have revolutionized cancer treatment. However, many cancers
are resistant to ICIs, and the targeting of additional inhibitory signals is crucial for limiting …

Although patients with microsatellite instable metastatic colorectal cancer (CRC) benefit from
immune checkpoint blockade, chemotherapy with targeted therapies remains the only …

Tumor antigen (TA)-targeting monoclonal antibody (mAb)-based treatments are considered
to be one of the most successful strategies in cancer therapy. Besides targeting TAs and …

Background Triple-negative breast cancer (TNBC) treatment is currently restricted to
chemotherapy. Hence, tumor-specific molecular targets and/or alternative therapeutic …

Macrophages play a central role in tissue homeostasis and host defense. However, the
properties of human macrophages in non-diseased tissues remain poorly understood. Here …

Although many patients with colorectal cancer initially respond to the chemotherapeutic
agent oxaliplatin, acquired resistance to this treatment remains a major challenge to the long …

Abstract γδ T cells contribute to the immune response against many cancers, notably
through their powerful effector functions that lead to the elimination of tumor cells and the …

Abstract Interleukin 17B (IL-17B) is a pro-inflammatory cytokine that belongs to the IL-17
cytokines family and binds to IL-17 receptor B (IL-17RB). Here we found that high …