[HTML][HTML] CXCL13 antibody for the treatment of autoimmune disorders

E Klimatcheva, T Pandina, C Reilly, S Torno… - BMC immunology, 2015 - Springer
Abstract Background Homeostatic B Cell-Attracting chemokine 1 (BCA-1) otherwise known
as CXCL13 is constitutively expressed in secondary lymphoid organs by follicular dendritic …

Antibody blockade of semaphorin 4D promotes immune infiltration into tumor and enhances response to other immunomodulatory therapies

EE Evans, AS Jonason Jr, H Bussler, S Torno… - Cancer immunology …, 2015 - AACR
Abstract Semaphorin 4D (SEMA4D, CD100) and its receptor plexin-B1 (PLXNB1) are
broadly expressed in murine and human tumors, and their expression has been shown to …

[HTML][HTML] SEMA4D compromises blood–brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease

ES Smith, A Jonason, C Reilly, J Veeraraghavan… - Neurobiology of …, 2015 - Elsevier
Multiple sclerosis (MS) is a chronic neuroinflammatory disease characterized by immune
cell infiltration of CNS, blood–brain barrier (BBB) breakdown, localized myelin destruction …

Generation and preclinical characterization of an antibody specific for SEMA4D

TL Fisher, CA Reilly, LA Winter, T Pandina, A Jonason… - MAbs, 2016 - Taylor & Francis
Semaphorin 4D (SEMA4D or CD100) is a member of the semaphorin family of proteins and
an important mediator of the movement and differentiation of multiple cell types, including …

Use of poxvirus display to select antibodies specific for complex membrane antigens

ES Smith, LA Balch, M Scrivens, S Shi, W Wang… - Mabs, 2023 - Taylor & Francis
Antibody discovery against complex antigens is limited by the availability of a reproducible
pure source of concentrated properly folded antigen. We have developed a technology to …

[HTML][HTML] 31st annual meeting and associated programs of the society for immunotherapy of cancer (Sitc 2016): Part two: National harbor, md, USA. 9-13 November …

C Ager, M Reilley, C Nicholas, T Bartkowiak… - … for ImmunoTherapy of …, 2016 - Springer
Background Despite the success of checkpoint blockade immunotherapy in
characteristically immunogenic cancers such as melanoma, these antibodies remain …

[HTML][HTML] Determination of the disulfide bonds within a B domain variant surface glycoprotein from Trypanosoma congolense

M Linder, D Linder, E Reinwald, H Bußler - Journal of Biological Chemistry, 1998 - ASBMB
The disulfide bonds within a variant surface glycoprotein from Trypanosoma congolense
have been determined. l-[35 S] Cysteine metabolically labeled protein was digested with …

Mouse strain specificity of the IgE response to the major allergens of Phleum pratense

U Seitzer, H Bussler, B Kullmann, A Petersen… - International archives of …, 2005 - karger.com
Background: IgE immune responses against major allergens from Phleum pratense in low-
and high-responder mouse strains were compared and the influence of alum was assessed …

Quantitative assessment of immediate cutaneous hypersensitivity in a mouse model exhibiting an IgE response to Timothy grass allergens.

U Seitzer, H Bussler, B Kullmann… - … Medical Journal of …, 2003 - europepmc.org
BACKGROUND: A variety of allergic reactions can be induced in mice, as measured by the
induction of specific IgE. Functional read-out parameters include skin reactions and airway …

[HTML][HTML] Antibody blockade of semaphorin 4D breaks down barriers to enhance tumoricidal immune infiltration and supports rational immunotherapy combinations

EE Evans, S Hu-Lieskovan, H Bussler, S Torno… - … for ImmunoTherapy of …, 2015 - Springer
Methods In vitro effects of SEMA4D and in vivo blockade of SEMA4D with monoclonal
murine antibody was evaluated in preclinical syngeneic models–tumor growth and immune …