Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast
An epistasis map (E-MAP) was constructed in the fission yeast, Schizosaccharomyces
pombe, by systematically measuring the phenotypes associated with pairs of mutations. This …
pombe, by systematically measuring the phenotypes associated with pairs of mutations. This …
[PDF][PDF] Reactivation of latent HIV-1 by inhibition of BRD4
HIV-1 depends on many host factors for propagation. Other host factors, however,
antagonize HIV-1 and may have profound effects on viral activation. Curing HIV-1 requires …
antagonize HIV-1 and may have profound effects on viral activation. Curing HIV-1 requires …
[HTML][HTML] Modulation of cellular disulfide-bond formation and the ER redox environment by feedback regulation of Ero1
Introduction of disulfide bonds into proteins entering the secretory pathway is catalyzed by
Ero1p, which generates disulfide bonds de novo, and Pdi1p, which transfers disulfides to …
Ero1p, which generates disulfide bonds de novo, and Pdi1p, which transfers disulfides to …
Systematic identification of synergistic drug pairs targeting HIV
X Tan, L Hu, LJ Luquette III, G Gao, Y Liu, H Qu… - Nature …, 2012 - nature.com
The systematic identification of effective drug combinations has been hindered by the
unavailability of methods that can explore the large combinatorial search space of drug …
unavailability of methods that can explore the large combinatorial search space of drug …
Dynamic behaviors of lipid-like self-assembling peptide A6D and A6K nanotubes
A Nagai, Y Nagai, H Qu, S Zhang - Journal of nanoscience and …, 2007 - ingentaconnect.com
Nanoscience and nanotechnology require development of nanomaterials that are amiable
for molecular design from bottom up. Molecular designer self-assembling peptides are one …
for molecular design from bottom up. Molecular designer self-assembling peptides are one …
[HTML][HTML] BND-22, a first-in-class humanized ILT2-blocking antibody, promotes antitumor immunity and tumor regression
I Mandel, DH Ziv, I Goldshtein, T Peretz… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Cancer immunotherapy has revolutionized cancer treatment. However,
considering the limited success of immunotherapy to only some cancer types and patient …
considering the limited success of immunotherapy to only some cancer types and patient …
[HTML][HTML] Comprehensive identification of host modulators of HIV-1 replication using multiple orthologous RNAi reagents
RNAi screens have implicated hundreds of host proteins as HIV-1 dependency factors
(HDFs). While informative, these early studies overlap poorly due to false positives and false …
(HDFs). While informative, these early studies overlap poorly due to false positives and false …
Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockade
R Greco, H Qu, H Qu, J Theilhaber, G Shapiro… - …, 2020 - Taylor & Francis
ABSTRACT TGFβ is a pleiotropic cytokine that may have both tumor inhibiting and tumor
promoting properties, depending on tissue and cellular context. Emerging data support a …
promoting properties, depending on tissue and cellular context. Emerging data support a …
[HTML][HTML] Selective Adsorption of Pb2+ in the Presence of Mg2+ by Layer-by-Layer Self-Assembled MnO2/Mxene Composite Films
H Qu, J Deng, D Peng, T Wei, H Zhang, R Peng - Processes, 2022 - mdpi.com
A self-assembled MnO2/Mxene composite film was compounded with MXene nanosheets
and layered crystalized MnO2 nanosheets using surfactant sodium dodecyl sulfate (SDS) as …
and layered crystalized MnO2 nanosheets using surfactant sodium dodecyl sulfate (SDS) as …
Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy
shRNAs can trigger effective silencing of gene expression in mammalian cells, thereby
providing powerful tools for genetic studies, as well as potential therapeutic strategies …
providing powerful tools for genetic studies, as well as potential therapeutic strategies …