STATs in cancer inflammation and immunity: a leading role for STAT3

H Yu, D Pardoll, R Jove - Nature reviews cancer, 2009 - nature.com
Commensurate with their roles in regulating cytokine-dependent inflammation and immunity,
signal transducer and activator of transcription (STAT) proteins are central in determining …

The STATs of cancer—new molecular targets come of age

H Yu, R Jove - Nature Reviews Cancer, 2004 - nature.com
Tumour cells acquire the ability to proliferate uncontrollably, resist apoptosis, sustain
angiogenesis and evade immune surveillance. STAT proteins—especially STAT3 and …

Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment

H Yu, M Kortylewski, D Pardoll - Nature reviews immunology, 2007 - nature.com
Immune cells in the tumour microenvironment not only fail to mount an effective anti-tumour
immune response, but also interact intimately with the transformed cells to promote …

A direct LDA algorithm for high-dimensional data—with application to face recognition

H Yu, J Yang - Pattern recognition, 2001 - Elsevier
Linear discriminant analysis (LDA) has been successfully used as a dimensionality
reduction technique to many classi" cation problems, such as speech recognition, face …

Revisiting STAT3 signalling in cancer: new and unexpected biological functions

H Yu, H Lee, A Herrmann, R Buettner, R Jove - Nature reviews cancer, 2014 - nature.com
Abstract The Janus kinases (JAKs) and signal transducer and activator of transcription
(STAT) proteins, particularly STAT3, are among the most promising new targets for cancer …

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

G Niu, KL Wright, M Huang, L Song, E Haura… - Oncogene, 2002 - nature.com
Non-receptor and receptor tyrosine kinases, such as Src and EGF receptor (EGFR), are
major inducers of vascular endothelial growth factor (VEGF), one of the most potent …

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

T Wang, G Niu, M Kortylewski, L Burdelya, K Shain… - Nature medicine, 2004 - nature.com
Although tumor progression involves processes such as tissue invasion that can activate
inflammatory responses, the immune system largely ignores or tolerates disseminated …

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

M Kortylewski, M Kujawski, T Wang, S Wei, S Zhang… - Nature medicine, 2005 - nature.com
The immune system can act as an extrinsic suppressor of tumors. Therefore, tumor
progression depends in part on mechanisms that downmodulate intrinsic immune …

IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway

L Wang, T Yi, M Kortylewski, DM Pardoll… - Journal of experimental …, 2009 - rupress.org
Although the Th17 subset and its signature cytokine, interleukin (IL)-17A (IL-17), are
implicated in certain autoimmune diseases, their role in cancer remains to be further …

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

R Garcia, TL Bowman, G Niu, H Yu, S Minton… - Oncogene, 2001 - nature.com
Constitutive activation of signal transducer and activator of transcription (STAT) proteins has
been detected in a wide variety of human primary tumor specimens and tumor cell lines …