User profiles for "author:Huilin Ma"

Huilin Ma

Bristol Myers Squibb
Verified email at bms.com
Cited by 477

Application oriented bioaugmentation processes: Mechanism, performance improvement and scale-up

H Ma, Y Zhao, K Yang, Y Wang, C Zhang, M Ji - Bioresource Technology, 2022 - Elsevier
Bioaugmentation is an optimization method with great potential to improve the treatment
effect by introducing specific strains into the biological treatment system. In this study, a …

Mechanism of antibacterial activity of choline-based ionic liquids (CAGE)

KN Ibsen, H Ma, A Banerjee, EEL Tanner… - ACS Biomaterials …, 2018 - ACS Publications
The continued emergence of antibiotic-resistant organisms has severely depleted our
arsenal of effective antimicrobials. Ionic liquids (ILs) show great promise as antibacterial …

Simulating Gram-negative bacterial outer membrane: a coarse grain model

H Ma, FJ Irudayanathan, W Jiang… - The Journal of Physical …, 2015 - ACS Publications
The cell envelope of Gram-negative bacteria contains a lipopolysaccharide (LPS) rich outer
membrane that acts as the first line of defense for bacterial cells in adverse physical and …

The influence of water on choline-based ionic liquids

EEL Tanner, KM Piston, H Ma, KN Ibsen… - ACS Biomaterials …, 2019 - ACS Publications
Choline and geranic acid (CAGE)-based ionic liquids have been recently developed for
applications in drug delivery. Understanding the microscopic structures of CAGE in the …

[HTML][HTML] Combination therapy with T cell engager and PD-L1 blockade enhances the antitumor potency of T cells as predicted by a QSP model

H Ma, H Wang, RJ Sové, J Wang… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background T cells have been recognized as core effectors for cancer immunotherapy. How
to restore the anti-tumor ability of suppressed T cells or improve the lethality of cytotoxic T …

QSP‐IO: a quantitative systems pharmacology toolbox for mechanistic multiscale modeling for Immuno‐oncology applications

RJ Sové, M Jafarnejad, C Zhao, H Wang… - CPT …, 2020 - Wiley Online Library
Immunotherapy has shown great potential in the treatment of cancer; however, only a
fraction of patients respond to treatment, and many experience autoimmune‐related side …

[HTML][HTML] Quantitative systems pharmacology model predictions for efficacy of atezolizumab and nab-paclitaxel in triple-negative breast cancer

H Wang, H Ma, RJ Sové, LA Emens… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Immune checkpoint blockade therapy has clearly shown clinical activity in
patients with triple-negative breast cancer, but less than half of the patients benefit from the …

[HTML][HTML] A quantitative systems pharmacology model of T cell engager applied to solid tumor

H Ma, H Wang, RJ Sove, M Jafarnejad, CH Tsai… - The AAPS Journal, 2020 - Springer
Cancer immunotherapy has recently drawn remarkable attention as promising results in the
clinic have shown its ability to improve the overall survival, and T cells are considered to be …

[HTML][HTML] Hyperspectral feature selection for SOM prediction using deep reinforcement learning and multiple subset evaluation strategies

L Zhao, K Tan, X Wang, J Ding, Z Liu, H Ma, B Han - Remote Sensing, 2022 - mdpi.com
It has been widely certified that hyperspectral images can be effectively used to monitor soil
organic matter (SOM). Though numerous bands reveal more details in spectral features …

Modeling diversity in structures of bacterial outer membrane lipids

H Ma, DD Cummins, NB Edelstein… - Journal of chemical …, 2017 - ACS Publications
Lipopolysaccharides (LPSs) are vital components of the outer membrane of Gram-negative
bacteria, and they act as extremely strong stimulators of innate immunity in diverse …