[HTML][HTML] Discovery of the cancer stem cell related determinants of radioresistance

C Peitzsch, I Kurth, L Kunz-Schughart… - Radiotherapy and …, 2013 - Elsevier
Tumors are known to be heterogeneous containing a dynamic mixture of phenotypically and
functionally different tumor cells. The two concepts attempting to explain the origin of …

Cancer biomarker discovery: current status and future perspectives

K Mäbert, M Cojoc, C Peitzsch, I Kurth… - … journal of radiation …, 2014 - Taylor & Francis
Purpose: Cancer is a multigene disease which arises as a result of mutational and
epigenetic changes coupled with activation of complex signaling networks. The use of …

Hypoxia as a biomarker for radioresistant cancer stem cells

C Peitzsch, R Perrin, RP Hill… - International journal of …, 2014 - Taylor & Francis
Background: Tumor initiation, growth and relapse after therapy are thought to be driven by a
population of cells with stem cell characteristics, named cancer stem cells (CSC). The …

Aldehyde dehydrogenase is regulated by β-catenin/TCF and promotes radioresistance in prostate cancer progenitor cells

M Cojoc, C Peitzsch, I Kurth, F Trautmann… - Cancer research, 2015 - AACR
Radiotherapy is a curative treatment option in prostate cancer. Nevertheless, patients with
high-risk prostate cancer are prone to relapse. Identification of the predictive biomarkers and …

[HTML][HTML] Cancer stem cell related markers of radioresistance in head and neck squamous cell carcinoma

I Kurth, L Hein, K Mäbert, C Peitzsch, L Koi, M Cojoc… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Despite recent advances in understanding of the molecular pathogenesis and improvement
of treatment techniques, locally advanced head and neck squamous cell carcinoma …

CXCR4 as biomarker for radioresistant cancer stem cells

F Trautmann, M Cojoc, I Kurth, N Melin… - … journal of radiation …, 2014 - Taylor & Francis
Purpose: Radioresistance of cancer cells remains a fundamental barrier for maximum
efficient radiotherapy. Tumor heterogeneity and the existence of distinct cell subpopulations …

[HTML][HTML] Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene …

H Bogumil, M Sill, D Schrimpf, B Ismer, C Blume… - Acta …, 2023 - Springer
Glioneuronal tumors are a heterogenous group of CNS neoplasms that can be challenging
to accurately diagnose. Molecular methods are highly useful in classifying these tumors …

[HTML][HTML] Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and …

J Nathansen, V Lukiyanchuk, L Hein, MI Stolte… - Oncogene, 2021 - nature.com
Head and neck squamous cell carcinoma (HNSCC) is often being diagnosed at an
advanced stage, conferring a poor prognosis. The probability of local tumor control after …

An epigenetic reprogramming strategy to resensitize radioresistant prostate cancer cells

C Peitzsch, M Cojoc, L Hein, I Kurth, K Mäbert… - Cancer research, 2016 - AACR
Radiotherapy is a mainstay of curative prostate cancer treatment, but risks of recurrence
after treatment remain significant in locally advanced disease. Given that tumor relapse can …

The CD98 heavy chain is a marker and regulator of head and neck squamous cell carcinoma radiosensitivity

D Digomann, I Kurth, A Tyutyunnykova, O Chen… - Clinical Cancer …, 2019 - AACR
Purpose: The heavy chain of the CD98 protein (CD98hc) is encoded by the SLC3A2 gene.
Together with the light subunit LAT1, CD98hc constitutes a heterodimeric transmembrane …